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Proteomics of 58 platinum-sensitive and 30 platinum-resistant ovarian cancer tissue-derived exosomes

ABSTRACT: In this study, 4D data-independent acquisition (DIA) proteomic sequencing was performed on exosomes obtained from 58 platinum-sensitive and 30 platinum-resistant patients with EOC. The analysis revealed a notable enrichment of differentially expressed proteins that were predominantly associated with immune-related pathways. Moreover, pivotal immune-related proteins (IRPs) were identified by LASSO regression. These factors, combined with clinical parameters selected through univariate logistic regression, were used for the construction of a model employing multivariate logistic regression.

INSTRUMENT(S): autoflex

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Oocyte

SUBMITTER: Shizhen Shen

LAB HEAD: Shizhen Shen

PROVIDER: PXD051500 | Pride | 2024-10-17

REPOSITORIES: Pride

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Publications

A Predictive Model for Initial Platinum-Based Chemotherapy Efficacy in Patients with Postoperative Epithelial Ovarian Cancer Using Tissue-Derived Small Extracellular Vesicles.

Shen Shizhen S Wang Conghui C Gu Jiaxin J Song Feifei F Wu Xiaodong X Qian Fangfang F Chen Xiaojing X Wang Lingfang L Peng Qiaohua Q Xing Ziyu Z Gu Lingkai L Wang Fenfen F Cheng Xiaodong X

Journal of extracellular vesicles 20240801 8

Epithelial ovarian cancer (EOC) is an often-fatal malignancy marked by the development of resistance to platinum-based chemotherapy. Thus, accurate prediction of platinum drug efficacy is crucial for strategically selecting postoperative interventions to mitigate the risks associated with suboptimal therapeutic outcomes and adverse effects. Tissue-derived extracellular vesicles (tsEVs), in contrast to their plasma counterparts, have emerged as a powerful tool for examining distinctive attributes ...[more]

PMID: 39104279

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microRNA profiling of platinum sensitive and platinum resistant high grade serous ovarian cancer samples

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miRNA profiling of longitudinal ovarian cancer biopsies collected before and after platinum-based neo-adjuvant chemotherapy

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