Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF HT
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): B Cell, Lymph Node
DISEASE(S): Lymphoma
SUBMITTER: Brendan Dwyer
LAB HEAD: Nathanael S.
PROVIDER: PXD051502 | Pride | 2024-12-20
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 18 |
Sarott Roman C RC Gourisankar Sai S Karim Basel B Nettles Sabin S Yang Haopeng H Dwyer Brendan G BG Simanauskaite Juste M JM Tse Jason J Abuzaid Hind H Krokhotin Andrey A Zhang Tinghu T Hinshaw Stephen M SM Green Michael R MR Crabtree Gerald R GR Gray Nathanael S NS
Science (New York, N.Y.) 20241004 6717
Kinases are critical regulators of cellular function that are commonly implicated in the mechanisms underlying disease. Most drugs that target kinases are molecules that inhibit their catalytic activity, but here we used chemically induced proximity to convert kinase inhibitors into activators of therapeutic genes. We synthesized bivalent molecules that link ligands of the transcription factor B cell lymphoma 6 (BCL6) to inhibitors of cyclin-dependent kinases (CDKs). These molecules relocalized ...[more]