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MTOR activity paces human blastocyst stage developmental progression

ABSTRACT: Many mammals can control the timing of gestation and birth by pausing embryonic development at the blastocyst stage. It is unknown whether the capacity to pause development is conserved, in general across mammals, and more specifically in humans. Activity of the growth regulating mTOR pathway governs developmental pausing in the mouse. Here we show a stage-specific capacity to delay the progression of human development via mTOR inhibition. In this context, human blastoids and pluripotent stem cells in naïve and naïve-like, but not primed, states can be induced to enter a dormant state, which is reversible at the functional and molecular level.

INSTRUMENT(S): timsTOF HT

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Pluripotent Stem Cell, Stem Cell

SUBMITTER: Richard Imre

LAB HEAD: Nicolas Rivron

PROVIDER: PXD052209 | Pride | 2024-09-16

REPOSITORIES: Pride

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			Action	DRS
	20231215_TimsHT_Heidari_Rivron_IMBA_id1434_DIA_800ng_HHK10_RD10_1_3676.d.rar	Other
	20231215_TimsHT_Heidari_Rivron_IMBA_id1434_DIA_800ng_HHK11_RD11_1_3678.d.rar	Other
	20231215_TimsHT_Heidari_Rivron_IMBA_id1434_DIA_800ng_HHK12_RD12_1_3680.d.rar	Other
	20231215_TimsHT_Heidari_Rivron_IMBA_id1434_DIA_800ng_HHK1_RD1_1_3652.d.rar	Other
	20231215_TimsHT_Heidari_Rivron_IMBA_id1434_DIA_800ng_HHK2_RD2_1_3654.d.rar	Other

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