A549 treated with CISPLATIN/TSA VS CONTROL
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Early Embryonic Cell
DISEASE(S): Colon Cancer
SUBMITTER: 
Yang Zhou
LAB HEAD: Zhou Yang
PROVIDER: PXD052305 | Pride | 2024-06-23
REPOSITORIES: Pride
Dataset's files
Publications
Trichostatin A Promotes Cytotoxicity of Cisplatin, as Evidenced by Enhanced Apoptosis/Cell Death Markers.
Zhou Yang Y Luo Qun Q Zeng Fangang F Liu Xingkai X Han Juanjuan J Gu Liangzhen L Tian Xiao X Zhang Yanyan Y Zhao Yao Y Wang Fuyi F
Molecules (Basel, Switzerland) 20240603 11
Trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor, promotes the cytotoxicity of the genotoxic anticancer drug cisplatin, yet the underlying mechanism remains poorly understood. Herein, we revealed that TSA at a low concentration (1 μM) promoted the cisplatin-induced activation of caspase-3/6, which, in turn, increased the level of cleaved PARP1 and degraded lamin A&C, leading to more cisplatin-induced apoptosis and G2/M phase arrest of A549 cancer cells. Both ICP-MS and ToF-SIMS measu ...[more]
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