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AMPK metabolics in T cells during GVHD

ABSTRACT: Evaluating role of AMPK in oxidative and glycolytic metabolism in T cells during graft-versus-host disease

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): T Cell

SUBMITTER: Richard Cattley

LAB HEAD: Craig Byersdorfer

PROVIDER: PXD052355 | Pride | 2024-10-17

REPOSITORIES: Pride

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			Action	DRS
	AMPK_Blood_Paper.xlsx	Xlsx
	KO-1.raw	Raw
	KO-2.raw	Raw
	KO-3.raw	Raw
	KO-4.raw	Raw

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Publications

AMPK drives both glycolytic and oxidative metabolism in murine and human T cells during graft-versus-host disease.

Ramgopal Archana A Braverman Erica L EL Sun Lee-Kai LK Monlish Darlene D Wittmann Christopher C Kemp Felicia F Qin Mengtao M Ramsey Manda J MJ Cattley Richard R Hawse William W Byersdorfer Craig A CA

Blood advances 20240801 15

<h4>Abstract</h4>Allogeneic T cells reprogram their metabolism during acute graft-versus-host disease (GVHD) in a process involving the cellular energy sensor adenosine monophosphate (AMP)-activated protein kinase (AMPK). Deletion of AMPK in donor T cells limits GVHD but still preserves homeostatic reconstitution and graft-versus-leukemia effects. In the current studies, murine AMPK knock-out (KO) T cells decreased oxidative metabolism at early time points posttransplant and lacked a compensator ...[more]

PMID: 38810258

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