Proteomics

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Tear Proteomics Analysis in Children and Adolescents with Type 1 Diabetes

ABSTRACT: Fifty-six children and adolescents with type 1 diabetes at least one year after diagnosis, aged 6-17 years old and fifty-six healthy age- and sex-matched subjects were enrolled in this cross-sectional study. Tear samples were collected using Schirmer strips placed on the lower eyelid. The proteomic analysis was based on a detergent-assisted protein extraction and their digestion from the tears, analysis of the tryptic peptides with LC-MS/ enabling the identification, and quantification of the Shirmer strip protein content via DIA-NN, and subsequently the statistical and bioinformatic analysis using the R and Metascape enrichment analysis tool.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Tear

DISEASE(S): Type 1 Diabetes Mellitus

SUBMITTER: Martina Samiotaki  

LAB HEAD: Nicolas C. Nicolaides

PROVIDER: PXD052994 | Pride | 2024-10-17

REPOSITORIES: Pride

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Publications

Tear Proteomics in Children and Adolescents with Type 1 Diabetes: A Promising Approach to Biomarker Identification of Diabetes Pathogenesis and Complications.

Angelopoulou Eleni E   Kitani Rosa-Anna RA   Stroggilos Rafael R   Lygirou Vasiliki V   Vasilakis Ioannis-Anargyros IA   Letsou Konstantina K   Vlahou Antonia A   Zoidakis Jerome J   Samiotaki Martina M   Kanaka-Gantenbein Christina C   Nicolaides Nicolas C NC  

International journal of molecular sciences 20240917 18

The aim of the current study was to investigate the tear proteome in children and adolescents with type 1 diabetes (T1D) compared to healthy controls, and to identify differences in the tear proteome of children with T1D depending on different characteristics of the disease. Fifty-six children with T1D at least one year after diagnosis, aged 6-17 years old, and fifty-six healthy age- and sex-matched controls were enrolled in this cross-sectional study. The proteomic analysis was based on liquid  ...[more]

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