Dataset Information
Angiotensinogen and C3 compete for renin-induced complement activation
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Charlotte Welinder
LAB HEAD: Diana Karpman
PROVIDER: PXD053116 | Pride | 2025-04-18
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 20240612_LysC_Abcam_Proteins.csv | Csv | |||
| 20240612_LysC_Abcam_Proteins.xlsx | Xlsx | |||
| Abcam_LysC_CW_X2404_281.raw | Raw |
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Publications
Angiotensinogen and C3 compete for renin-induced complement activation.
Frontiers in immunology 20250402
Renin from plasma, kidney, and recombinant sources was previously demonstrated to cleave C3 to C3a and C3b. C3a was generated at a similar rate to that by C3 convertase, and C3 cleavage was inhibited by the renin inhibitor aliskiren. Renin endogenously produced by Calu6 cells also led to C3 deposition on cells. These results have been challenged by another group suggesting that recombinant renin does not cleave C3 or that renin was contaminated by trypsin, which also cleaves C3. Here, we investi ...[more]
