Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Osteoblastoma
SUBMITTER: Gopal Sapkota
LAB HEAD: Dr Gopal Sapkota
PROVIDER: PXD053311 | Pride | 2024-08-09
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
BIDIPIC_TP.pdStudy | Other | |||
TFEB_BIDIPIC_TP_1.msf | Msf | |||
TFEB_BIDIPIC_TP_1.msfView | Msf | |||
TFEB_BIDIPIC_TP_1.pdResult | Other | |||
TFEB_BIDIPIC_TP_1.pdResultView | Other |
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iScience 20240629 8
Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular responses to metabolic and other stresses. During nutrient replete and stressor-free conditions, phosphorylated TFEB is primarily localized to the cytoplasm. Stressor-mediated reduction of TFEB phosphorylation promotes its nuclear translocation and context-dependent transcriptional activity. In this study, we explored targeted dephosphorylation of TFEB as an approach to activate TFEB in the absence of nutrient ...[more]