Vec-STING LS-MS and US2 STING LS-MS
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: 
Zhengjie Kong
LAB HEAD: Zhengjie Kong
PROVIDER: PXD053353 | Pride | 2024-08-09
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 1_Vec.raw | Raw | |||
| 2_US.raw | Raw | |||
| 3.xlsx | Xlsx | |||
| checksum.txt | Txt |
Items per page: 5 1 - 4 of 4 |
Publications
Pseudorabies virus tegument protein US2 antagonizes antiviral innate immunity by targeting cGAS-STING signaling pathway.
Kong Zhengjie Z Chen Xing X Gong Lele L Wang Lele L Zhang Yifeng Y Guan Kaifeng K Yao Wanzi W Kang Yu Y Lu Xinyi X Zhang Yuhang Y Du Yongkun Y Sun Aijun A Zhuang Guoqing G Zhao Jianguo J Wan Bo B Zhang Gaiping G
Frontiers in immunology 20240702
<h4>Background</h4>The cGAS-STING axis-mediated type I interferon pathway is a crucial strategy for host defense against DNA virus infection. Numerous evasion strategies developed by the pseudorabies virus (PRV) counteract host antiviral immunity. To what extent PRV-encoded proteins evade the cGAS-STING signaling pathway is unknown.<h4>Methods</h4>Using US2 stably expressing cell lines and US2-deficient PRV model, we revealed that the PRV tegument protein US2 reduces STING protein stability and ...[more]
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