Ring study of patients suffering from focal segmental glomerulosclerosis as a proof of concept for federated proteomics.
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ABSTRACT: Quantitative mass spectrometry has transformed proteomics by allowing the simultaneous quantification of thousands of proteins. To boost statistical power, it is necessary to increase sample sizes by combining patient-derived data from various institutions. However, this practice raises significant privacy concerns. We created this dataset comtaining 30 healthy donors and 30 patients suffering from focal segmental glomerulosclerosis - a rare kidney disease - and distributed them to three independent proteomics centers. This distributed data were used as a proof of concept to introduce FedProt - the first privacy-preserving tool for collaborative differential protein abundance analysis of distributed data.
INSTRUMENT(S): Orbitrap Fusion Lumos, Orbitrap Exploris 480, Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Serum
DISEASE(S): Focal Segmental Glomerulosclerosis
SUBMITTER: Johannes Schmidt
LAB HEAD: Stefan Kalkhof
PROVIDER: PXD053560 | Pride | 2024-08-08
REPOSITORIES: Pride
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