Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Embryo, Oocyte
SUBMITTER: Chen Li
LAB HEAD: Chen Li
PROVIDER: PXD054371 | Pride | 2025-02-05
REPOSITORIES: Pride
Action | DRS | |||
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202407_mEm_turnover_upload.xlsx | Xlsx | |||
mEm_CHX_12h_1.d.rar | Other | |||
mEm_CHX_12h_2.d.rar | Other | |||
mEm_CHX_3h_1.d.rar | Other | |||
mEm_CHX_3h_2.d.rar | Other |
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Cell 20250123 3
Understanding mammalian preimplantation development, particularly in humans, at the proteomic level remains limited. Here, we applied our comprehensive solution of ultrasensitive proteomic technology to measure the proteomic profiles of oocytes and early embryos and identified nearly 8,000 proteins in humans and over 6,300 proteins in mice. We observed distinct proteomic dynamics before and around zygotic genome activation (ZGA) between the two species. Integrative analysis with translatomic dat ...[more]