Dataset Information
Endo-IP and Lyso-IP Toolkit for Endolysosomal Profiling of Human Induced Neurons
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Eclipse, Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Embryonic Stem Cell
SUBMITTER: 
Miguel A. Gonzalez-Lozano
LAB HEAD: J. Wade Harper
PROVIDER: PXD055978 | Pride | 2025-01-11
REPOSITORIES: pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 593018_a30342.mzid.gz | Mzid | |||
| 593019_a30343.mzid.gz | Mzid | |||
| 593020_a30344.mzid.gz | Mzid | |||
| 593021_a30345.mzid.gz | Mzid | |||
| 593022_a30346.mzid.gz | Mzid |
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Publications
Endo-IP and lyso-IP toolkit for endolysosomal profiling of human-induced neurons.
Proceedings of the National Academy of Sciences of the United States of America 20241205 52
Plasma membrane protein degradation and recycling are regulated by the endolysosomal system, wherein endocytic vesicles bud from the plasma membrane into the cytoplasm and mature into endosomes and then degradative lysosomes. As such, the endolysosomal system plays a critical role in determining the abundance of proteins on the cell surface and influencing cellular identity and function. Highly polarized cells, like neurons, rely on the endolysosomal system for axonal and dendritic specializatio ...[more]
