Dataset Information

Unconventional RNA-binding proteins in mitosis

ABSTRACT: Ribonucleoprotein complexes are dynamic assemblies of RNA associated with RNA-binding proteins (RBPs), which can modulate the fate of the RNA molecules from transcription to degradation. Dysregulation of RBPs is linked to diseases such as cancer and neurological disorders, which motivated the development of multiple approaches to catalog RBPs. RNA and RBPs are present in mitotic structures like the centrosomes and spindle microtubules, but their influence on mitotic spindle integrity remains unknown. The unconventional RNA-binding protein AURKA is investigated. Mass spectrometry analysis was used to identify AURKA RNA-dependent interaction partners.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hela Cell

SUBMITTER: Maiwen Caudron-Herger

LAB HEAD: Maïwen Caudron-Herger

PROVIDER: PXD056233 | Pride | 2025-02-25

REPOSITORIES: Pride

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An atlas of RNA-dependent proteins in cell division reveals the riboregulation of mitotic protein-protein interactions.

Rajagopal Varshni V Seiler Jeanette J Nasa Isha I Cantarella Simona S Theiss Jana J Herget Franziska F Kaifer Bianca B Klostermann Melina M Will Rainer R Schneider Martin M Helm Dominic D König Julian J Zarnack Kathi K Diederichs Sven S Kettenbach Arminja N AN Caudron-Herger Maïwen M

Nature communications 20250308 1

Ribonucleoprotein complexes are dynamic assemblies of RNA with RNA-binding proteins, which modulate the fate of RNA. Inversely, RNA riboregulates the interactions and functions of the associated proteins. Dysregulation of ribonucleoprotein functions is linked to diseases such as cancer and neurological disorders. In dividing cells, RNA and RNA-binding proteins are present in mitotic structures, but their impact on cell division remains unclear. By applying the proteome-wide R-DeeP strategy to ce ...[more]

PMID: 40057470

			Action	DRS
	UP000005640_9606.fasta	Fasta
	mqpar.xml	Xml
	oecf3-VR0536-01.raw	Raw
	oecf3-VR0536-02.raw	Raw
	oecf3-VR0536-03.raw	Raw

Dataset Information

Unconventional RNA-binding proteins in mitosis

Dataset's files

Publications

An atlas of RNA-dependent proteins in cell division reveals the riboregulation of mitotic protein-protein interactions.

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