Proteomics

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Shatavari Supplementation During Eight Weeks of Resistance Training Increases Training Load, Enhances Skeletal Muscle Contractility and Alters the Skeletal Muscle Proteome in Older Women.


ABSTRACT: Shatavari is a herbal dietary supplement that may increase skeletal muscle strength in younger and older adults. Shatavari contains compounds with both estradiol-like and antioxidant properties, which could enhance muscle function. Postmenopausal women may derive the greatest benefit, as estrogen deficiency adversely impacts skeletal muscle function. However, mechanistic insights are limited and the effects of shatavari on muscle function require further characterization. In this randomised, double-blind trial, 17 young (23 ±5yr) and 22 older (63±5yr) women completed an eight-week leg resistance training programme. They consumed either a placebo or shatavari (1000mg/d, equivalent to 26,500 mg/d fresh weight) supplement throughout. Pre and post training, measures of leg strength, neuromuscular function and vastus lateralis (VL) biopsies were obtained. Tandem-mass-tagged VL proteomic analyses were performed. Additionally, resistance training (RT) is the gold standard intervention for ameliorating sarcopenia. Outstanding mechanistic questions remain regarding the malleability of the molecular determinants of skeletal muscle function in older age. Discovery proteomics can expand such knowledge. We further aimed to compare the effect of RT on the skeletal muscle proteome and neuromuscular function (NMF) in older and younger women.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Skeletal Muscle

SUBMITTER: Mary O'Leary  

LAB HEAD: Dr Mary

PROVIDER: PXD056507 | Pride | 2024-10-22

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
270623_15Plex_Exp1_PS.msf Msf
270623_15Plex_Exp3_PS.msf Msf
270623_15Plex_Exp4_PS.msf Msf
270623_5Plex_Exp2_PS.msf Msf
270623_Exp1_Fraction_1.raw Raw
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