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STRUCTURE OF APOLIPOPROTEIN B100 BOUND TO LOW-DENSITY LIPOPROTEIN RECEPTOR

ABSTRACT: Apolipoprotein B100 (apoB100) is the main structural protein on Low-density Lipoproteins (LDL) and is the principal ligand for the LDL receptor (LDLR). Because the tertiary structure of apoB100 on LDL has not been determined, the detailed molecular interaction between apoB100 and LDLR is unknown. Here we present the structures of LDL bound to the LDLR and an apoB100 nanobody complex at 4.18Å resolution and a second LDL-LDLR interface at 4.83Å resolution.

INSTRUMENT(S): Orbitrap Eclipse

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Anthony Ciancone

LAB HEAD: Francis J.

PROVIDER: PXD056510 | Pride | 2024-12-06

REPOSITORIES: Pride

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			Action	DRS
	E231128_01_AMC_Mart_LDLandLDLR_SulfoSDA_007MolarRatio_pepSEC_Frac1_10sDE_Inj1.raw	Raw
	E231128_02_AMC_Mart_LDLandLDLR_SulfoSDA_007MolarRatio_pepSEC_Frac2_10sDE_Inj1.raw	Raw
	E231128_03_AMC_Mart_LDLandLDLR_SulfoSDA_007MolarRatio_pepSEC_Frac3_10sDE_Inj1.raw	Raw
	E231128_05_AMC_Mart_LDLandLDLR_SulfoSDA_007MolarRatio_pepSEC_Frac4_10sDE_Inj1.raw	Raw
	E231128_06_AMC_Mart_LDLandLDLR_SulfoSDA_007MolarRatio_pepSEC_Frac5_10sDE_Inj1.raw	Raw

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STRUCTURE OF APOLIPOPROTEIN B100 BOUND TO LOW-DENSITY LIPOPROTEIN RECEPTOR (SDA ASPN XL DATA)

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