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Mass spectrometry analysis of degenerated human intervertebral disc tissues

ABSTRACT: Mass spectrometry analysis of degenerated human intervertebral disc tissues obtained during elective surgery to treat low back pain

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Nucleus Pulposus Cell Of Intervertebral Disc, Intervertebral Disc

DISEASE(S): Degenerative Disc Disease

SUBMITTER: Christabel Dube

LAB HEAD: Dr Stephen Richardson

PROVIDER: PXD056620 | Pride | 2025-02-14

REPOSITORIES: pride

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	20220607_HoylandJ_GilbertH_1in2_5_01.raw	Raw
	20220607_HoylandJ_GilbertH_1in2_5_03.raw	Raw
	20220607_HoylandJ_GilbertH_1in2_5_05.raw	Raw
	20220607_HoylandJ_GilbertH_1in2_5_06.raw	Raw
	20220607_HoylandJ_GilbertH_1in2_5_07.raw	Raw

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Publications

Proteomic profiling of human plasma and intervertebral disc tissue reveals matrisomal, but not plasma, biomarkers of disc degeneration.

Dube Christabel Thembela CT Gilbert Hamish T J HTJ Rabbitte Niamh N Baird Pauline P Patel Sonal S Herrera Jeremy A JA Baricevic-Jones Ivona I Unwin Richard D RD Chan Danny D Gnanalingham Kanna K Hoyland Judith A JA Richardson Stephen M SM

Arthritis research & therapy 20250210 1

<h4>Background</h4>Intervertebral disc (IVD) degeneration is a common cause of low back pain, and the most symptomatic patients with neural compression need surgical intervention to relieve symptoms. Current techniques used to diagnose IVD degeneration, such as magnetic resonance imaging (MRI), do not detect changes in the tissue extracellular matrix (ECM) as degeneration progresses. Improved techniques, such as a combination of tissue and blood biomarkers, are needed to monitor the progression ...[more]

PMID: 39930483

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