Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Eclipse
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Suspension Culture, T Cell
SUBMITTER: Ekaterina Vinogradova
LAB HEAD: Ekaterina Viktorovna Vinogradova
PROVIDER: PXD056704 | Pride | 2024-10-21
REPOSITORIES: Pride
Items per page: 1 - 5 of 265 |
bioRxiv : the preprint server for biology 20231218
Despite significant interest in therapeutic targeting of splicing, few chemical probes are available for the proteins involved in splicing. Here, we show that elaborated stereoisomeric acrylamide chemical probe EV96 and its analogues lead to a selective T cell state-dependent loss of interleukin 2-inducible T cell kinase (ITK) by targeting one of the core splicing factors SF3B1. Mechanistic investigations suggest that the state-dependency stems from a combination of differential protein turnover ...[more]