Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro 2, timsTOF HT
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Eric Fischer
LAB HEAD: Eric Fischer
PROVIDER: PXD057393 | Pride | 2024-12-06
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
esf4_7665_Slot2-1_1_2358.d.zip | Other | |||
esf4_7666_Slot2-2_1_2359.d.zip | Other | |||
esf4_7667_Slot2-3_1_2360.d.zip | Other | |||
esf4_7668_Slot2-4_1_2361.d.zip | Other | |||
esf4_7671_Slot2-7_1_2366.d.zip | Other |
Items per page: 5 1 - 5 of 22 |
Bailey Henry J HJ Eisert Jonathan J Kazi Rubina R Gerhartz Jan J Pieńkowska Dominika Ewa DE Dressel Ina I Vollrath Joshua J Kondratov Ivan I Matviyuk Tetiana T Tolmachova Nataliya N Shah Varun Jayeshkumar VJ Giuliani Giulio G Mosler Thorsten T Geiger Thomas M TM Esteves Ana M AM Santos Sandra P SP Sousa Raquel L RL Bandeiras Tiago M TM Leibrock Eva-Maria EM Bauer Ulrike U Leuthner Birgitta B Langer Julian D JD Wegener Ansgar A AA Nowak Radosław P RP Sorrell Fiona J FJ Dikic Ivan I
Cell chemical biology 20241120
The majority of clinical degraders utilize an immunomodulatory imide drug (IMiD)-based derivative that directs their target to the E3 ligase receptor cereblon (CRBN); however, identification of IMiD molecular glue substrates has remained underexplored. To tackle this, we design human CRBN constructs, which retain all features for ternary complex formation, while allowing generation of homogenous and cost-efficient expression in E. coli. Extensive profiling of the construct shows it to be the "be ...[more]