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Oral delivery of a cholera toxin-binding protein protects against diarrhoea in experimental cholera

ABSTRACT: Oral cholera vaccines (OCVs) have become important components of strategies for cholera control, but the demand for OCVs has outstripped the supply2–4. There is a need for new cholera control measures for the one billion people living in cholera endemic regions5. The use of orally delivered single-domain antibodies has been proposed as a potential approach for the control of gastrointestinal pathogens6. Here, we describe the development of an orally deliverable bivalent VHH construct (BL3.2) that binds to the B-subunit of cholera toxin (CTXB). The epitope of CTXB for binding molecule BL3.2 was mapped by Hydrogen Deuterium Exchange HDX

INSTRUMENT(S): Synapt MS

ORGANISM(S): Vibrio Cholerae H1

DISEASE(S): Cholera

SUBMITTER: Dario Segura-Pena

LAB HEAD: Nikolina Sekulic

PROVIDER: PXD057713 | Pride | 2025-02-24

REPOSITORIES: pride

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			Action	DRS
	CTXB_data.zip	Other
	plgs_ouputCtxB_ND01_20240930131015.zip	Other
	plgs_outputCtxB_ND01_20240930131036.zip	Other
	plgs_outputCtxB_ND02_20240930131648.zip	Other
	plgs_outputCtxB_ND02_20240930131707.zip	Other

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