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Quantitative proteomics identifies plasma protein alterations that associate with metabolic and thrombotic profile changes after bariatric surgery

ABSTRACT: This study involved the collection of 25 (16 female and nine male adults) plasma samples from bariatric surgery patients. Plasma was prepared from blood samples taken pre-surgery (within 48 hours, files with the suffix ‘Pre’) and nine months post-surgery (files with the suffix ‘Post’).

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Obesity

SUBMITTER: Marco Fernandes

LAB HEAD: Sally Shirran

PROVIDER: PXD057848 | Pride | 2025-03-17

REPOSITORIES: Pride

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			Action	DRS
	220218_Hasnain_nondep_plasma_frac01.raw	Raw
	220218_Hasnain_nondep_plasma_frac02.raw	Raw
	220218_Hasnain_nondep_plasma_frac03.raw	Raw
	220218_Hasnain_nondep_plasma_frac04.raw	Raw
	220218_Hasnain_nondep_plasma_frac05.raw	Raw

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Quantitative proteomics identifies plasma protein alterations that associate with metabolic and thrombotic profile changes after bariatric surgery.

Ahmed Hasnain H Fernandes Marco F MF Abbas Kazim K Synowsky Silvia A SA Shirran Sally L SL Ajjan Ramzi A RA Stewart Alan J AJ

Diabetes, obesity & metabolism 20250225

<h4>Objective</h4>Roux-en-Y gastric bypass (RYGB) surgery has been shown to lead to favourable health outcomes in obese patients. However, the molecular changes that occur and how they relate to clinical measures are poorly understood. Here, we characterise the proteomic alterations that occur in plasma of RYGB patients before and 9 months after surgery using quantitative proteomics.<h4>Methods</h4>Plasma proteomics was performed by sequential window acquisition of all theoretical fragment ion s ...[more]

PMID: 40000393

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