Proteomics

Dataset Information

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Quantitative proteomics of DAAO-TGTie2 aorta


ABSTRACT: We pursued a chemogenetic approach to create an animal model of aortic aneurysm formation using a transgenic mouse line DAAO-TGTie2 that expresses yeast D-amino acid oxidase (DAAO) under control of the endothelial Tie2 promoter. In DAAO-TGTie2 mice, DAAO generates the reactive oxygen species hydrogen peroxide (H2O2) in endothelial cells only when provided with D-amino acids. When DAAO-TGTie2 mice are chronically fed D-alanine, the animals become hypertensive and develop abdominal but not thoracic aortic aneurysms. Generation of H2O2 in the endothelium leads to oxidative stress throughout the vascular wall.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Aorta

SUBMITTER: Thomas Michel  

LAB HEAD: Prof.Thomas Michel

PROVIDER: PXD060737 | Pride | 2025-02-18

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
JM10657.raw Raw
JM10658.raw Raw
JM10659.raw Raw
JM10660.raw Raw
JM10661.raw Raw
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