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Mus musculus strain:C57BL/6J

ABSTRACT: Transcriptome analysis of murine skeletal muscle of Nrf2 KO mice in space.

PROVIDER: PRJDB10745 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR255414_1.fastq.gz	Fastqsanger.gz
	DRR255414_2.fastq.gz	Fastqsanger.gz
	DRR255415_1.fastq.gz	Fastqsanger.gz
	DRR255415_2.fastq.gz	Fastqsanger.gz
	DRR255416_1.fastq.gz	Fastqsanger.gz

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Project description:To elucidate roles that Nrf2 plays in regulating adaptive responses to the space stress, one month-long space travel and RNA-seq analysis of six Nrf2-KO mice and six wild-type mice were conducted . After 31-days-stay in the ISS, all the flight mice returned safely to Earth. We found that Nrf2 was indeed activated by the space stress in various tissues. The space stress and Nrf2-deficiency brought about changes in gene expression.

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Characterizing phenotypic data of Peromyscus leucopus compared to C57BL/6J Mus musculus and diversity outbred (DO) Mus musculus.

Project description:Translational research is commonly performed in the C57B6/J mouse strain, chosen for its genetic homogeneity and phenotypic uniformity. Here, we evaluate the suitability of the white-footed deer mouse (Peromyscus leucopus) as a model organism for aging research, offering a comparative analysis against C57B6/J and diversity outbred (DO) Mus musculus strains. Our study includes comparisons of body composition, skeletal muscle function, and cardiovascular parameters, shedding light on potential applications and limitations of P. leucopus in aging studies. Notably, P. leucopus exhibits distinct body composition characteristics, emphasizing reduced muscle force exertion and a unique metabolism, particularly in fat mass. Cardiovascular assessments showed changes in arterial stiffness, challenging conventional assumptions and highlighting the need for a nuanced interpretation of aging-related phenotypes. Our study also highlights inherent challenges associated with maintaining and phenotyping P. leucopus cohorts. Behavioral considerations, including anxiety-induced responses during handling and phenotyping assessment, pose obstacles in acquiring meaningful data. Moreover, the unique anatomy of P. leucopus necessitates careful adaptation of protocols designed for Mus musculus. While showcasing potential benefits, further extensive analyses across broader age ranges and larger cohorts are necessary to establish the reliability of P. leucopus as a robust and translatable model for aging studies.

| S-EPMC11335981 | biostudies-literature

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