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Pyricularia oryzae

ABSTRACT: DNA methylation analysis of Pyricularia oryzae

PROVIDER: PRJDB10949 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	DRR260206_1.fastq.gz	Fastqsanger.gz
	DRR260206_2.fastq.gz	Fastqsanger.gz
	DRR260207_1.fastq.gz	Fastqsanger.gz
	DRR260207_2.fastq.gz	Fastqsanger.gz
	DRR260208_1.fastq.gz	Fastqsanger.gz

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Project description:We report different roles of three PRC2 components, KMT6, P55 and SIN3 played in distribution of genome-wide H3K27 tri-methylation of Pyricularia oryzae. Polycomb repressive complex 2 (PRC2), which is composed of Ezh(Kmt6), Su(z)12, Esc(Eed) and accessory subunits RbAp48/Nurf55(P55), catalyzes the methylation of histone H3 at lysine 27. Loss of P55 caused severe global defects in the normal distribution of H3K27me3 and transcriptional reprogramming on the H3K27me3-occupied genes. Furthermore, we found that the Sin3 histone deacetylase complex was required to sustain H3K27me3 occupancy and stably maintain gene repression by directly interacting with P55.

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