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Rattus norvegicus strain:Zucker fatty

ABSTRACT: Transcriptome analysis of pancreatic islets of Zucker fatty rats

PROVIDER: PRJDB12053 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR311027_1.fastq.gz	Fastqsanger.gz
	DRR311027_2.fastq.gz	Fastqsanger.gz
	DRR311028_1.fastq.gz	Fastqsanger.gz
	DRR311028_2.fastq.gz	Fastqsanger.gz
	DRR311029_1.fastq.gz	Fastqsanger.gz

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Zucker diabetic fatty (ZDF)/Zucker lean control (ZLC) comparisons

Project description:Gene expression profiles in tissues of Zucker diabetic fatty (ZDF) rats compared with age matched Zucker lean control (ZLC) rats. Keywords: other

2004-03-01 | GSE1080 | GEO

Expression data from rosiglitazone treated, rosiglitazone withdrawal and untreated control Zucker Diabetic Fatty rats.

Project description:Insulin resistance and islet failure are the two etiological roots of type 2 diabetes mellitus, and understanding global islet gene expression may provide insight into the mechanisms that regulate islet function. In this study we systematically investigated the gene expression profile and proliferative response of islets to insulin sensitization, insulin resistance, and islet failure. Five-week old male Zucker Diabetic Fatty rats (n=24) were randomized into one of three groups: four-week rosiglitazone treated, rosiglitazone withdrawal, or untreated controls. Affymetrix GeneChip Rat Genome 230 2.0 gene arrays were performed on isolated islets to measure the gene expression profile of islets at 9, 11, and 13 weeks of age.

2013-06-21 | E-GEOD-30147 | biostudies-arrayexpress

Zucker Diabetic Fatty (ZDF) Rat Study - Diaphragm vs. Sternohyoid

Project description:Type 2 diabetes differs from type 1 diabetes in its pathogenesis. Type 1 diabetic diaphragm has altered gene expression which includes lipid and carbohydrate metabolism, ubiquitination and oxidoreductase activity. The objectives of the present study were to assess respiratory muscle gene expression changes in type 2 diabetes and to determine whether they are greater for the diaphragm than an upper airway muscle. Diaphragm and sternohyoid muscle from Zucker diabetic fatty (ZDF) rats were analyzed with Affymetrix gene expression arrays. The two muscles had 97 and 102 genes, respectively, with at least ±1.5-fold significantly changed expression with diabetes, and these were assigned to gene ontology groups based on over-representation analysis. Several significantly changed groups were common to both muscles, including lipid metabolism, carbohydrate metabolism, muscle contraction, ion transport and collagen, although the number of genes and the specific genes involved differed considerably for the two muscles. In both muscles there was a shift in metabolism gene expression from carbohydrate metabolism toward lipid metabolism, but the shift was greater and involved more genes in diabetic diaphragm than diabetic sternohyoid muscle. Groups present in only diaphragm were blood circulation and oxidoreductase activity. Groups present in only sternohyoid were immune & inflammation and response to stress & wounding, with complement genes being a prominent component. In conclusion, type 2 diabetes-induced gene expression changes in respiratory muscles has both similarities and differences relative to previous data on type 1 diabetes gene expression. Furthermore, the diabetic alterations in gene expression differ between diaphragm and sternohyoid. 18-week-old Zucker diabetic fatty rats: 6 normal and 5 diabetic diaphragms and sternohyoids.

2014-05-12 | E-GEOD-21791 | biostudies-arrayexpress

Rattus norvegicus breed:Zucker fa/fa

Project description:Zucker rat Metagenome

| PRJNA380082 | ENA

Rattus norvegicus

Project description:Zucker diabetic fatty (ZDF)/Zucker lean control (ZLC) comparisons

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The differentially expressed genes of Zucker Diabetic Fatty Rats treated with Berberine against diabetes mellitus

Project description:The anti-diabetes activity of Rhizoma Coptidis was documented in the book âNotes of Elite Physiciansâ written by Hongjing Tao 1500 years ago. Berberine (BBR) is the major isoquinoline alkaloid constituent of the Chinese herb Rhizoma Coptidis, which has the beneficial characteristic of regulating glucose and lipid metabolism and has been extensively used in the treatment of obesity, diabetes and hypercholesterolemia. However, the effect of berberine on specific diabetes treatment targets is unknown. This study was conducted to elucidate the genome-wide gene expression profile in Zucker Diabetic Fatty Rats liver tissues in response to Berberine treatment.

2016-11-30 | E-MTAB-5178 | biostudies-arrayexpress

Influence of dietary whole egg on the transcriptome in Zucker Diabetic Fatty rats

Project description:Here we analyzed how whole egg consumption in Zucker Diabetic Fatty (ZDF) rats alters microRNA and mRNA expression across the adipose, liver, kidney, and prefrontal cortex tissue. Male ZDF (fa/fa) rats (n = 12) and their lean controls (fa/+) (n = 12) were obtained at 6 wk of age. Rats had ad libitum access to water and were randomly assigned to a modified semi-purified AIN93G casein-based diet or a whole egg-based diet, both providing 20% protein (w/w). TotalRNA libraries were prepared using QuantSeq 3' mRNA-Seq and Lexogen smallRNA library prep kits and were further sequenced on an Illumina HighSeq3000. Differential gene expression was conducted using DESeq2 in R and Benjamini-Hochberg adjusted P- values controlling for false discovery rate at 5%.We identified 9 microRNAs and 583 genes that were differentially expressed in response to 8 wk of consuming whole egg-based diets.

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Project description:Expression data from rosiglitazone treated, rosiglitazone withdrawal and untreated control Zucker Diabetic Fatty rats.

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2007-10-11 | E-GEOD-665 | biostudies-arrayexpress

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