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Saccharomyces cerevisiae strain:BY4741

ABSTRACT: Unveiling the intracellular stress responses, introduced and induced by higher level of glutathione using S. cerevisiae

PROVIDER: PRJDB12811 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR342972_1.fastq.gz	Fastqsanger.gz
	DRR342972_2.fastq.gz	Fastqsanger.gz
	DRR342973_1.fastq.gz	Fastqsanger.gz
	DRR342973_2.fastq.gz	Fastqsanger.gz
	DRR342974_1.fastq.gz	Fastqsanger.gz

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Quantitative transcriptome analysis of a high-GSH producing Saccharomyces cerevisiae and the wild type based on the second generation sequencing.

Project description:The mutant Saccharomyces cerevisiae Y518 generated much more intracellular glutathione (GSH) than its counterpart dose. The RNA-seq based global transcriptome analysis was performed for exploring the potential mechanisms. Statistical analysis indicated that 1125 differentially expressed genes (fold-change>=2.0, FDR<=0.001) were up-regulated and 503 were down-regulated. There were 12 genes involved in glutathione metabolism. Of which GSH1, encodes gamma-glutamine cysteine synthetase, the rate-limiting enzyme in GSH biosynthesis process, was up-regulated. And MET17, encodes cysteine synthase A, an enzyme catalyzes the biosynthesis of one of the precursor amino acids L- cysteine, was also up-regulated. Besides, regulator SKN7 and several genes involved in oxidative stress response (GPX2, CTT1, SOD1, TRX2) were up-regulated. Intracellular ROS level of Y518 was also enhanced compared to that of 2-10515. Our results indicate that up-regulations of GSH1 and MET17 might be associated with the increased intracellular GSH content of the mutant, and up-regulated GSH1 may be caused by increased intracellular ROS level. Saccharomyces cerevisiae mRNA profiles of 24-h wild type 2-10515 and mutant Y518 were generated by deep sequencing using Illumina HiSeqTM 2000

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