Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mus musculus

ABSTRACT: Transcriptome analysis of murine spinal cord in space.

PROVIDER: PRJDB13049 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	DRR346890_1.fastq.gz	Fastqsanger.gz
	DRR346890_2.fastq.gz	Fastqsanger.gz
	DRR346891_1.fastq.gz	Fastqsanger.gz
	DRR346891_2.fastq.gz	Fastqsanger.gz
	DRR346892_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Mus musculus

Project description:Murine Spastic Spinal Cord

| PRJNA90603 | ENA

Mus musculus

Project description:Spinal Cord Injury Murine Model

| PRJNA96419 | ENA

Mus musculus

Project description:mouse spinal cord Transcriptome

| PRJNA1200241 | ENA

Tenascin-C modifies expression levels and territories of key patterning genes during spinal cord astrocyte specification [mus musculus]

Project description:We demonstrate for the first time that the extracellular matrix glycoprotein Tenascin-C regulates the expression of key patterning genes during late embryonic spinal cord development, leading to a timely maturation of gliogenic neural precursor cells. We first show that Tenascin-C is expressed by gliogenic neural precursor cells during late embryonic development. The loss of Tenascin-C leads to a sustained generation and delayed migration of Fibroblast growth factor receptor 3 expressing immature astrocytes in vivo. Furthermore, we could demonstrate an upregulation of Nk2 transcription factor related locus 2 (Nkx2.2) and its downstream target Sulfatase 1 in vivo. A dorsal expansion of Nkx2.2-positive cells within the ventral spinal cord indicates a potential progenitor cell domain shift. Moreover, Sulfatase 1 is known to regulate growth factor signalling by cleaving sulphate residues from heparan sulphate proteoglycans. Consistent with this possibility we observed changes in both Fibroblast growth factor 2 and Epidermal growth factor responsiveness of spinal cord neural precursor cells. Taken together our data clearly show that Tenascin-C promotes the astroglial lineage progression during spinal cord development.

2011-10-20 | GSE33091 | GEO

Mus musculus

Project description:Analysis of the host transcriptome from demyelinating spinal cord of murine coronavirus infected mice

| PRJNA189553 | ENA

Tenascin-C modifies expression levels and territories of key patterning genes during spinal cord astrocyte specification [mus musculus]

2011-10-19 | E-GEOD-33091 | biostudies-arrayexpress

Mus musculus

Project description:Mus musculus Spinal Cord Transcriptome

| PRJNA438014 | ENA

Mus musculus

Project description:Transcriptome analysis of murine dorsal root ganglion in space.

| PRJDB14659 | ENA