ABSTRACT: Gene expression profiling in the rat epididymis exposed to p-cumylphenol, m-cresol,2,3-dimethylbenzenamine, dicyclohexylcarbodiimide and diheptyl phthalate. CIBEX accession: CBX198
Project description:Gene expression profiling in the rat liver exposed to p-cumylphenol, m-cresol,2,3-dimethylbenzenamine, dicyclohexylcarbodiimide and diheptyl phthalate CIBEX accession: CBX242.
Project description:Gene expression profiling in the rat lung exposed to p-cumylphenol, m-cresol,2,3-dimethylbenzenamine, dicyclohexylcarbodiimide and diheptyl phthalate. CIBEX accession: CBX213
Project description:Gene expression profiling in the rat kidney exposed to p-cumylphenol, m-cresol,2,3-dimethylbenzenamine, dicyclohexylcarbodiimide and diheptyl phthalate. CIBEX accession: CBX234
Project description:Gene expression profiling in the rat spleen exposed to p-cumylphenol, m-cresol,2,3-dimethylbenzenamine, dicyclohexylcarbodiimide, and diheptyl phthalate. CIBEX accession: CBX154
Project description:Gene expression profiling in the rat testes exposed to p-cumylphenol, m-cresol,2,3-dimethylbenzenamine, dicyclohexylcarbodiimide and diheptyl phthalate. CIBEX accession: CBX195
Project description:Gene expression profiling in the rat prostate exposed to p-cumylphenol, m-cresol,2,3-dimethylbenzenamine, dicyclohexylcarbodiimide, and diheptyl phthalate. CIBEX accession: CBX119
Project description:Gene expression profiling in the rat duodenum exposed to p-cumylphenol, m-cresol,2,3-dimethylbenzenamine, dicyclohexylcarbodiimide, and diheptyl phthalate. CIBEX accession: CBX123
Project description:Gene expression profiling in the rat subcutaneous adipose tissue exposed to p-cumylphenol, m-cresol,2,3-dimethylbenzenamine, dicyclohexylcarbodiimide and diheptyl phthalate. CIBEX accession: CBX228
Project description:Exposure to environmental chemicals during windows of development is a potentially contributing factor in gut microbiota dysbiosis, and linked to chronic diseases and developmental disorders. We used a community-level model of microbiota metabolism to investigate the effects of diethylhexyl phthalate (DEHP), a ubiquitous plasticizer implicated in neurodevelopmental disorders, on the composition and metabolite outputs of gut microbiota in young mice. Administration of DEHP by oral gavage increased the abundance of Lachnoclostridum, while decreasing Akkermansia, Odoribacter, and Clostridium sensu stricto. Addition of DEHP to in vitro cultured cecal microbiota increased the abundance of Alistipes, Paenibacillus, and Lachnoclostridium. Untargeted metabolomics showed that DEHP broadly altered the metabolite profile in the culture. Notably, DEHP enhanced the production of p-cresol, while inhibiting butyrate synthesis. Metabolic model-guided correlation analysis indicated that the likely sources of p-cresol are Clostridium species. Our results suggest that DEHP can directly modify the microbiota to affect production of bacterial metabolites linked with neurodevelopmental disorders.
