Project description:Populations of engineered metabolite-producing microorganisms are prone to evolutionary production declines during industrial-scale cultivations. In this study, we develop a synthetic product addiction system in E coli that addicts mevalonic acid production cells to mevalonic acid. Through experimentally simuluated long-term fermentation, we investigate how product-addicted organisms remain stable and avoid formation of genetic subpopulations of fit, non-producing cells.
Project description:Transcriptional response to growth with arsenite by the haloalkaliphilic sulfur-oxidizer Thioalkalivibrio thiocyanoxidans ARh2 and Tv. jannaschii by performing RNA-seq analysis
Project description:Transcriptional response to growth at low temperature in the haloalkaliphilic sulfur-oxidizer Thioalkalivibrio versutus AL2 and Tv. nitratis ALJ2 by performing RNA-seq analysis
Project description:Aeromicrobium massiliense strain JC14(T)sp. nov. is the type strain of Aeromicrobium massiliense sp. nov., a new species within the genus Aeromicrobium. This strain, whose genome is described here, was isolated from the fecal microbiota of an asymptomatic patient. Aeromicrobium massiliense is an aerobic rod-shaped gram-positive bacterium. Here we describe the features of this organism, together with the complete genome sequence and annotation. The 3,322,119 bp long genome contains 3,296 protein-coding and 51 RNA genes.