Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Severe acute respiratory syndrome coronavirus 2

ABSTRACT: SELEX based aptamers: An excellent diagnostic and entry inhibitor therapeutic for SARS-CoV-2

PROVIDER: PRJDB15927 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

SARS-CoV-2

Project description:SELEX based aptamers: An excellent diagnostic and entry inhibitor therapeutic for SARS-CoV-2

| PRJNA975735 | ENA

Severe acute respiratory syndrome coronavirus 2

Project description:SARS-CoV-2 Genome sequencing and assembly from Rapid Diagnostic Tests

| PRJNA971982 | ENA

Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress responses and apoptosis

Project description:Severe acute respiratory syndrome virus (SARS-CoV) that lacks the envelope (E) gene (rSARS-CoV-ΔE) is attenuated in vivo [1,2]. To identify factors that contribute to rSARS-CoV-ΔE attenuation, gene expression in cells infected by SARS-CoV with or without E gene was compared. Twenty-five stress response genes were preferentially upregulated during infection in the absence of the E gene. In addition, genes involved in signal transduction, transcription, cell metabolism, immunoregulation, inflammation, apoptosis and cell cycle and differentiation were differentially regulated in cells infected with rSARS-CoV with or without the E gene. Administration of E protein in trans reduced the stress response in cells infected with rSARS-CoV-ΔE, with respiratory syncytial virus, or treated with drugs, such as tunicamycin and thapsigarcin that elicit cell stress by different mechanisms. In addition, SARS-CoV E protein down-regulated the signaling pathway inositol-requiring enzyme 1 (IRE-1) of the unfolded protein response, but not the PKR-like ER kinase (PERK) or activating transcription factor 6 (ATF-6) pathways, and reduced cell apoptosis. Overall, the activation of the IRE-1 pathway was not able to restore cell homeostasis, and apoptosis was induced probably as a meassure to protect the host by limiting virus production and dissemination. The expression of proinflammatory cytokines was reduced in rSARS-CoV-ΔE-infected cells compared to rSARS-CoV-infected cells, suggesting that the increase in stress responses and the reduction of inflammation in the absence of the E gene contributed to the attenuation of rSARS-CoV-ΔE. We used Affymetrix microarrays (Human Genome U133 plus 2.0) to compare global gene expression between SARS-CoV-infected, mock-infected and SARS-CoV-ΔE-infected cells. For ech type of sample three hybridizations were carried-out (independent biological replicates).

2012-06-20 | E-GEOD-30589 | biostudies-arrayexpress

Severe acute respiratory syndrome-associated coronavirus infection.

Project description:Whether severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infection can be asymptomatic is unclear. We examined the seroprevalence of SARS-CoV among 674 healthcare workers from a hospital in which a SARS outbreak had occurred. A total of 353 (52%) experienced mild self-limiting illnesses, and 321 (48%) were asymptomatic throughout the course of these observations. None of these healthcare workers had antibody to SARS CoV, indicating that subclinical or mild infection attributable to SARS-CoV in adults is rare.

| S-EPMC3035556 | biostudies-literature

Severe acute respiratory syndrome coronavirus 2 isolate:USA-WA1/2020

Project description:A rapid, low cost, and highly sensitive SARS-CoV-2 diagnostic based on whole genome sequencing

| PRJNA1035777 | ENA

Severe acute respiratory syndrome coronavirus 2

Project description:Experimental infection of hamsters with wild-type and nsp14-P203L SARS-CoV-2

| PRJDB14156 | ENA

Severe acute respiratory syndrome coronavirus 2

Project description:Favipiravir therapy on SARS-CoV-2

| PRJDB11237 | ENA

Severe acute respiratory syndrome coronavirus 2

Project description:Severe acute respiratory syndrome coronavirus 2 Genome sequencing and assembly

| PRJNA667434 | ENA

Severe acute respiratory syndrome-related coronavirus

Project description:Severe acute respiratory syndrome-related coronavirus overview

| PRJNA69689 | ENA

Severe acute respiratory syndrome coronavirus 2

Project description:SARS-CoV-2 genomic data and descriptive metadata from primary specimens collected in British Columbia, Canada during the COVID-19 outbreak.

| PRJNA699623 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data