Archaea
Ontology highlight
ABSTRACT:
PROVIDER: PRJDB16552 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:NBRC representative bacterial strains Genome sequencing project
| PRJDB14606 | ENA
Project description:NBRC representative eukaryotes strains Genome sequencing project
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Project description:NBRC representative bacterial strains Genome sequencing project
| PRJDB16551 | ENA
Project description:Archaeal 5S Ribosomal RNA RefSeq Targeted Loci Project
| PRJNA188107 | ENA
Project description:Archaeal 23S Ribosomal RNA RefSeq Targeted Loci Project
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Project description:Archaeal 16S Ribosomal RNA RefSeq Targeted Loci Project
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Project description:Chemical communication is crucial in ecosystems with complex microbial assemblages. However, due to archaeal cultivation challenges, our understanding of the structure diversity and function of secondary metabolites (SMs) within archaeal communities is limited compared to the extensively studied and well-documented bacterial counterparts. Our comprehensive investigation into the biosynthetic potential of archaea, combined with metabolic analyses and the first report of heterologous expression in archaea, has unveiled the previously unexplored biosynthetic capabilities and chemical diversity of archaeal ribosomally synthesized and post-translationally modified peptide (RiPP). We have identified twenty-four new lanthipeptides of RiPPs exhibiting unique chemical characteristics, including a novel subfamily featuring an unexplored type with diamino-dicarboxylic (DADC) termini, largely expanding the chemical landscape of archaeal SMs. This sheds light on the chemical novelty of archaeal metabolites and emphasizes their potential as an untapped resource for natural product discovery. Additionally, archaeal lanthipeptides demonstrate specific antagonistic activity against haloarchaea, mediating the unique biotic interaction in the halophilic niche. Furthermore, they showcased a unique ecological role in enhancing the host's motility by inducing the rod-shaped cell morphology and upregulating the archaellum gene flgA1, facilitating the archaeal interaction with abiotic environments. These discoveries broaden our understanding of archaeal chemical language and provide promising prospects for future exploration of SM-mediated interaction.
2024-11-09 | GSE281021 | GEO
Project description:Bacterial and Archaeal 16S Ribosomal RNA RefSeq Targeted Loci Project
| PRJNA33175 | ENA
Project description:Bacterial and Archaeal 23S Ribosomal RNA RefSeq Targeted Loci Project
| PRJNA188943 | ENA
Project description:Bacterial and Archaeal 5S Ribosomal RNA RefSeq Targeted Loci Project
| PRJNA188106 | ENA