Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Candidatus Prometheoarchaeum syntrophicum

ABSTRACT: Co-cultivation of Promethearchaeum syntrophicum MK-D1 and Halodesulfovibrio MK-HDV

PROVIDER: PRJDB17953 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	DRR544851_1.fastq.gz	Fastqsanger.gz
	DRR544851_2.fastq.gz	Fastqsanger.gz
	DRR544852_1.fastq.gz	Fastqsanger.gz
	DRR544852_2.fastq.gz	Fastqsanger.gz
	DRR544853_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Candidatus Prometheoarchaeum syntrophicum strain:MK-D1

Project description:Candidatus Prometheoarchaeum syntrophicum strain:MK-D1 Genome sequencing and assembly

| PRJNA557562 | ENA

Candidatus Prometheoarchaeum syntrophicum

Project description:anaerobic archaeon MK-D1 overview

| PRJNA601036 | ENA

Candidatus Prometheoarchaeum syntrophicum

Project description:Transcriptome analysis of anaerobic archaeon MK-D1

| PRJDB9032 | ENA

Whole-cell proteome of Promethearchaeum syntrophicum strain MK-D1

Project description:Identification of the proteins from tryptic digests of Promethearchaeum syntrophicum strain MK-D1 whole-cell proteome followed by nanoLC/OrbitrapFusion MS analysis.

2024-07-16 | PXD051006 | JPOST Repository

Halodesulfovibrio sp. MK-HDV

Project description:Halodesulfovibrio sp. MK-HDV Genome sequencing and assembly

| PRJNA557563 | ENA

Candidatus Thiodictyon syntrophicum str. Cad16

Project description:candidatus Thiodictyon syntrophicum sp. nov. strain Cad16 Proteome

| PRJNA81947 | ENA

Candidatus Thiodictyon syntrophicum strain:Cad16T

Project description:Candidatus 'Thiodictyon syntrophicum' sp.nov. Cad16T Genome sequencing and assembly

| PRJNA354524 | ENA

Sporotomaculum syntrophicum strain:FB

Project description:Sporotomaculum syntrophicum strain:FB Genome sequencing and assembly

| PRJNA309719 | ENA

An Hepatitis B and D Virus Infection Model Using Human Pluripotent Stem Cell-Derived Hepatocyte-Like Cells for Virus Host Interactions and Antiviral Evaluation

Project description:Current culture systems available for studying hepatitis D virus (HDV) are suboptimal. In this study, we demonstrate that hepatocyte-like cells (HLCs) derived from human pluripotent stem cells (hPSCs) are fully permissive to HDV infection across various tested genotypes. When co- infected with the helper hepatitis B virus (HBV) or transduced to express the HBV envelope protein HBsAg, HLCs effectively release infectious progeny virions. We also show that HLCs expressing HBsAg support extracellular spread of HDV, thus providing a valuable platform for testing available anti-HDV regimens. By challenging the cells along the differentiation with HDV infection, we have identified CD63 as a potential HDV/HBV co-entry factor, which was rate-limiting HDV infection in immature hepatocytes. Given their renewable source and the potential to derive hPSCs from individual patients, we propose HLCs as a promising model for investigating HDV biology. Our findings offer new insights into HDV infection and expand the repertoire of research tools available for the development of therapeutic interventions.

2024-07-29 | GSE270625 | GEO

Hepatitis D infection induces IFN-β-mediated NK cell activation and TRAIL-dependent cytotoxicity

Project description:The co-infection of hepatitis B (HBV) patients with the hepatitis D virus (HDV) causes the most severe form of viral hepatitis and thus drastically worsens the course of the disease. Therapy options for HBV/HDV patients are still limited. Here, we investigated the potential of natural killer (NK) cells that are crucial drivers of the innate immune response against viruses to target HDV-infected hepatocytes. We established in vitro co-culture models using HDV-infected hepatoma cell lines and human peripheral blood NK cells. We determined NK cell activation by flow cytometry, transcriptome analysis, bead-based cytokine immunoassays, and NK cell-mediated effects on T cells by flow cytometry. We validated the mechanisms using CRISPR/Cas9-mediated gene deletions. Moreover, we assessed the frequencies and phenotype of NK cells in peripheral blood of HBV and HDV superinfected patients. Upon co-culture with HDV-infected hepatic cell lines, NK cells upregulated activation markers, interferon-stimulated genes (ISGs) including the death receptor ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), produced interferon (IFN)-gamma and eliminated HDV-infected cells via the TRAIL-TRAIL-R2 axis. We identified IFN-beta released by HDV-infected cells as an important enhancer of NK cell activity. In line with our in vitro data, we observed activation of peripheral blood NK cells from HBV/HDV co-infected, but not HBV mono-infected patients. Our data demonstrate NK cell activation in HDV infection and their potential to eliminate HDV-infected hepatoma cells via the TRAIL/TRAIL-R2 axis which implies a high relevance of NK cells for the design of novel anti-viral therapies.

2023-12-04 | GSE249240 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data