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Hepacivirus hominis

ABSTRACT: Prevalence of hepatitis C virus subgenotypes 1a and 1b in Japanese patients: ultra-deep sequencing analysis of HCV NS5B genotype-specific region

PROVIDER: PRJDB2394 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR013280.fastq.gz	Fastqsanger.gz
	DRR013281.fastq.gz	Fastqsanger.gz
	DRR013282.fastq.gz	Fastqsanger.gz
	DRR013283.fastq.gz	Fastqsanger.gz
	DRR013284.fastq.gz	Fastqsanger.gz

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Hepacivirus hominis

Project description:Prevalence of hepatitis C virus subgenotypes 1a and 1b in Japanese patients: ultra-deep sequencing analysis of HCV NS5B genotype-specific region

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Project description:Hepatitis C Virus (HCV) has a extremely narrow host cell tropism and robustly infects only very few cell lines, most importantly the human hepatoma cell line Huh7. This cell line was isolated from a 57-year old Japanese male with fulminant hepatitis. Different subclones and passages of the Huh7 cell line show up to 1000-fold differences in HCV replication efficiency (permissiveness). In this experiment, we sought to identify factors responsible for these differences by correlating gene expression from eight different uninfected Huh7 variants with their respective HCV permissiveness. HCV replication efficiency was determined using electroporation of a subgenomic luciferase reporter replicon (genotype 1b, "con1/ET") and measuring luciferase activity at 48h post transfection normalized to the input value at 4h p.t.. "Relative permissiveness" of cell lines corresponds to their replication efficiency, normalized to the efficiency in the lowest permissive cells (Huh7 p13 and p28).

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