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Ascoidea asiatica

ABSTRACT: NBRP: Genome sequencing of Ascoidea asiatica JCM 7603

PROVIDER: PRJDB3724 | ENA |

REPOSITORIES: ENA

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Dataset's files

Source:

			Action	DRS
	BCKQ01.dat.gz	Other
	BCKQ01.fasta.gz	Fasta.gz
	BCKQ01.master.dat	Other
	DRR037285_1.fastq.gz	Fastqsanger.gz
	DRR037285_2.fastq.gz	Fastqsanger.gz

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Yeast genetic codes - Endogenous Stochastic Decoding of the CUG Codon by Competing Ser- and Leu-tRNAs in Ascoidea asiatica

Project description:While the “universal” genetic code is now known not to be universal, and stop codons can have multiple meanings, one regularity remains, namely that for a given sense codon there is a unique translation. Examining CUG usage in yeasts that have transferred CUG away from leucine, we here report the first example of dual coding: Ascoidea asiatica stochastically encodes CUG as both serine and leucine. This is deleterious as evidenced by CUG codons being rare, never at conserved serine/leucine residues and predominantly in lowly expressed genes. Related yeasts solve the problem by loss-of-function of one of the two tRNAs. This dual-coding is consistent with the tRNA-loss driven codon reassignment hypothesis and provides a unique example of a proteome that cannot be deterministically predicted.

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