Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dictyostelium discoideum

ABSTRACT: Analysis of Biological Soliton

PROVIDER: PRJDB4205 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	DRR046814_1.fastq.gz	Fastqsanger.gz
	DRR046814_2.fastq.gz	Fastqsanger.gz
	DRR046815_1.fastq.gz	Fastqsanger.gz
	DRR046815_2.fastq.gz	Fastqsanger.gz
	DRR046816_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Dictyostelium discoideum

Project description:Analysis of Biological Soliton

| PRJDB3922 | ENA

Developmental commitment in Dictyostelium discoideum.

Project description:Upon starvation, Dictyostelium discoideum cells halt cell proliferation, aggregate into multicellular organisms, form migrating slugs, and undergo morphogenesis into fruiting bodies while differentiating into dormant spores and dead stalk cells. At almost any developmental stage cells can be forced to dedifferentiate when they are dispersed and diluted into nutrient broth. However, migrating slugs can traverse lawns of bacteria for days without dedifferentiating, ignoring abundant nutrients and continuing development. We now show that developing Dictyostelium cells revert to the growth phase only when bacteria are supplied during the first 4 to 6 h of development but that after this time, cells continue to develop regardless of the presence of food. We postulate that the cells' inability to revert to the growth phase after 6 h represents a commitment to development. We show that the onset of commitment correlates with the cells' loss of phagocytic function. By examining mutant strains, we also show that commitment requires extracellular cyclic AMP (cAMP) signaling. Moreover, cAMP pulses are sufficient to induce both commitment and the loss of phagocytosis in starving cells, whereas starvation alone is insufficient. Finally, we show that the inhibition of development by food prior to commitment is independent of contact between the cells and the bacteria and that small soluble molecules, probably amino acids, inhibit development during the first few hours and subsequently the cells become unable to react to the molecules and commit to development. We propose that commitment serves as a checkpoint that ensures the completion of cooperative aggregation of developing Dictyostelium cells once it has begun, dampening the response to nutritional cues that might inappropriately block development.

| S-EPMC2168402 | biostudies-literature

Dictyostelium discoideum

Project description:Social amoeba that is a powerful model organism for studying cellular and developmental processes

| PRJNA9565 | ENA

Dictyostelium discoideum

Project description:Structural and functional analyses of full-length cDNAs

| PRJNA12621 | ENA

Dictyostelium discoideum

Project description:Global Transcriptional Responses to Cisplatin in Dictyostelium discoideum Identify Potential Drug Targets

| PRJNA101251 | ENA

Dictyostelium discoideum

Project description:Dictyostelium discoideum Genome sequencing

| PRJNA313527 | ENA

Dictyostelium discoideum

Project description:Investigation of differential expression: Differentiating cells vs Salmonella infected cells (t6)

| PRJNA129609 | ENA

Dictyostelium discoideum

Project description:Investigation of differential expression: Differentiating cells vs Salmonella infected cells (t3)

| PRJNA129613 | ENA

Dictyostelium discoideum

Project description:The small RNA repertoire of Dictyostelium discoideum

| PRJNA102027 | ENA

Dictyostelium discoideum

Project description:The retinoblastoma orthologue, rblA, is a major regulator of S-phase, mitotic, and developmental gene expression in Dictyostelium

| PRJNA143419 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data