Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mouse gut metagenome

ABSTRACT: Aging-related alteration of the murine intestinal environment induces an obese-type gut dysbiosis

PROVIDER: PRJDB4909 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	DRR062723.fastq.gz	Fastqsanger.gz
	DRR062724.fastq.gz	Fastqsanger.gz
	DRR062725.fastq.gz	Fastqsanger.gz
	DRR062726.fastq.gz	Fastqsanger.gz
	DRR062727.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 119

Similar Datasets

Global transcriptional profiles of intestinal epithelial cells during aging [scRNA-seq]

Project description:We report aging-induced transcriptional alteration of mouse intestinal epithelial cells. Our analyses revealed that age-related changes occur in a cell-type-specific manner.

2025-02-06 | GSE210241 | GEO

mouse gut metagenome

Project description:Aging-related alterations of murine intestinal microbiota

| PRJDB9487 | ENA

Gut microbiota transplantation in conventional mice

Project description:Gut microbiota dysbiosis characterizes systemic metabolic alteration, yet its causality is debated. To address this issue, we transplanted antibiotic-free conventional wild-type mice with either dysbiotic (“obese”) or eubiotic (“lean”) gut microbiota and fed them either a NC or a 72%HFD. We report that, on NC, obese gut microbiota transplantation reduces hepatic gluconeogenesis with decreased hepatic PEPCK activity, compared to non-transplanted mice. Of note, this phenotype is blunted in conventional NOD2KO mice. By contrast, lean microbiota transplantation did not affect hepatic gluconeogenesis. In addition, obese microbiota transplantation changed both gut microbiota and microbiome of recipient mice. Interestingly, hepatic gluconeogenesis, PEPCK and G6Pase activity were reduced even once mice transplanted with the obese gut microbiota were fed a 72%HFD, together with reduced fed glycaemia and adiposity compared to non-transplanted mice. Notably, changes in gut microbiota and microbiome induced by the transplantation were still detectable on 72%HFD. Finally, we report that obese gut microbiota transplantation may impact on hepatic metabolism and even prevent HFD-increased hepatic gluconeogenesis. Our findings may provide a new vision of gut microbiota dysbiosis, useful for a better understanding of the aetiology of metabolic diseases. all livers are from NC-fed mice only.

2017-03-16 | GSE81318 | GEO

Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease

Project description:Braak’s hypothesis stating that sporadic Parkinson’s disease follows a specific progression of the pathology from the peripheral to the central nervous system and can be monitored by detecting accumulation of the alpha-Synuclein protein. There is growing interest in understanding how the gut (commensal) microbiome can regulate alpha-Synuclein accumulation which can lead to PD. We studied a transgenic rat model overexpressing the human alpha-Synuclein and found that the protein overexpression resulted in gut alpha-Synuclein expression and aggregation in the gut neurons with advancing age. A progressive gut microbial composition alteration characterized by the reduction of Firmicutes to Bacteroidetes ratio could be detected in the young transgenic rat model and interestingly this ratio was then increased with aging. This observation was accompanied in older animals by intestinal inflammation, increase gut permeability and a robust alteration in metabolites production characterized by the increase of succinate level in the feces and serum. Manipulation of the gut bacteria by short-term antibiotics treatment revealed a complete loss of short-chain fatty acids (SCFAs) and reduction in succinate levels. Although antibiotics treatment did not change alpha-synuclein expression in the enteric nervous system of the colon, it can reduce alpha-synuclein expression in the olfactory bulb of the transgenic rats. In summary, synchronous with ageing, our data emphasize that the gut microbiome dysbiosis leads to a specific alteration of gut metabolites which are reflected in the serum and can be modulated by the environment.

2023-06-28 | GSE236012 | GEO

Mouse liver and kidney proteome with antibiotics treatment

Project description:Dysbiosis (alteration of intestinal flora) is associated with various host physiologies, including diseases. The purpose of this study was to clarify the effect of dysbiosis on protein expression levels in mouse liver and kidney by quantitative proteomic analysis, focusing in particular on drug-metabolizing enzymes and transporters in order to investigate the potential impact of dysbiosis on drug pharmacokinetics.

2018-01-01 | PXD008237 | JPOST Repository

JPST000349-3 Mouse liver and kidney proteome with antibiotics treatment [Reanalysis: JPST000349]

2023-04-01 | RPXD034311 | JPOST Repository

JPST000349-9 Mouse liver and kidney proteome with antibiotics treatment [Reanalysis: JPST000349]

2023-04-01 | RPXD034317 | JPOST Repository

JPST000349-11 Mouse liver and kidney proteome with antibiotics treatment [Reanalysis: JPST000349]

2023-04-01 | RPXD034319 | JPOST Repository

JPST000349-4 Mouse liver and kidney proteome with antibiotics treatment [Reanalysis: JPST000349]

2023-04-01 | RPXD034312 | JPOST Repository

JPST000349-8 Mouse liver and kidney proteome with antibiotics treatment [Reanalysis: JPST000349]

2023-04-01 | RPXD034316 | JPOST Repository