Project description:The gut bacterium Coprococcus sp. ART55/1 has been found to encode two genes containing glycoside hydrolase family 9 (GH9) catalytic domains. These genes are hypothesised to impact upon the ability of this bacteria to utilise different carbon sources. To further investigate the role of these genes, as well as the wider transcriptome, Coprococcus sp. ART55/1 was grown on five different carbon sources - beta-glucan, lichenan, cellobiose, glucose and glucomannan - and the transcriptional response was investigated using RNA sequencing.
Project description:A novel propionate production pathway from inositol by commensal Anaerostipes which is known as intestinal butyrate producer was studied. The physiological relevance of this pathway was explored in human gut as well as potential health impact of Anaerostipes species to the human host.
