Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Han Chinese Trio PacBio Whole Genome Sequencing

ABSTRACT: PacBio Whole Genome Sequencing to identify structural variation in Han Chinese Trio

PROVIDER: PRJEB12236 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Expression data from coronary heart disease in Chinese Han people

Project description:The genetics, social, cultural and environmental factors pose a great challenge for the diagnosis and treatment of coronary heart disease among different racial groups. We aimed to identify the differentially expressed genes involved in coronary heart disease in Chinese Han people as an aid for screening and diagnosing coronary heart disease. We used microarrays to detail the global programme of gene expression to identify the differentially gene between the patients with coronary heart disease and healthy people in Chinese Han people

2015-07-23 | GSE71226 | GEO

Expression data from coronary heart disease in Chinese Han people

2015-07-23 | E-GEOD-71226 | biostudies-arrayexpress

Differential gene expression profiles in peripheral blood in Northeast Chinese Han people with acute myocardial infarction

Project description:The genes had different expression between healthy people and acute myocardial infarction.We aimed to identify the differentially expressed genes involved in acute myocardial infarction in Northeast Chinese Han people. We used microarrays to detail the global programme of gene expression to identify the differentially gene between the patients with acute myocardial infarction and healthy people in Northeast Chinese Han people

2017-04-04 | GSE97320 | GEO

Mapping of Hepatic Expression Quantitative Trait Loci (eQTLs) in a Han Chinese Population [Expression analysis]

Project description:Elucidating the genetic basis underlying the variation in hepatic gene expression is of importance to understand disease etiology and drug metabolism variances. To date, no genome-wide eQTL analysis has been conducted in the Han Chinese, the largest ethnic group in the world. We performed a genome-wide eQTL mapping in a set of Han Chinese liver tissue (n=64).

2015-01-02 | GSE53791 | GEO

Mapping of hepatic expression quantitative trait loci (eQTLs) in a Han Chinese population [SNP analysis]

2015-01-02 | GSE53790 | GEO

Epigenome analysis of Chinese Han male semen samples

Project description:Genome wide DNA methylation profiling of Chinese Han male semen samples. The Illumina Human Methylation 450 Beadchip was used to obtain DNA methylation profiles across approximately 450,000 CpGs. Samples included 3 young males (aged 24, 25 and 25 years old) and 3 aged males (aged 63, 60 and 55 years old).

2018-06-19 | GSE115920 | GEO

Methylation Patterns in Han Chinese Neural Tube Defects Pedigrees

Project description:In this study, in 3 Han Chinese NTD pedigrees (2 with multiple affected children), with no information on folic acid deficiency or supplement, we examined genome-wide methylation profiles of each individual in these families.

2016-12-15 | E-MTAB-5320 | biostudies-arrayexpress

Novel Rare Copy Number Variants Associated with Tetralogy of Fallot in the Han Chinese Population

Project description:Tetralogy of Fallot (TOF), the most frequent cyanotic congenital heart disease, occurs as a simplex trait of unknown etiology in the majority of cases. Studies of non-Asian populations suggest that approximately 10% of TOF cases carry a de novo rare copy number variant (CNV) thought to underlie the malformation. A genome-wide CNV analysis was performed in 303 TOF and 302 controls of Han Chinese as well as compared to 1,000 common Chinese database and revealed 166 rare CNVs identified in TOF patients with 119 CNVs further evaluated as potential “TOF-specific CNVs”; 98 were validated by qPCR, and 44 CNVs showed positive results on validation (positive rate 46.9%, 44/98). The genes related to the clinical phenotypes (subpulmonary VSD, bicuspid pulmonary valve, aortic valve overriding more than 75%, and right aortic arch) and the specific CNVs were included in integrating gene-gene interaction network analysis that identified the genes covering the specific CNVs directly or indirectly correlated to TOF and the signaling pathways. Thus, this study identified novel TOF-specific/associate CNVs in the Han Chinese that occurring at higher frequency in the Han Chinese (28.4% in Chr 1-20 and 42.9% in all chromosomes) is reflective of the increased prevalence of TOF in China. These novel CNVs identify new candidate genes for TOF. Our findings provide new insight into the contribution of CNVs to the genetic basis of TOF and identify new genetic loci potentially important to the pathogenesis of TOF

2021-01-01 | GSE151767 | GEO

De novo assembled individual genome does not show advantage against standard reference genome: a demonstration of Chinese Han Population

Project description:We compared standard human reference genome GRCh38 and de novo assembled reference genome HX1 in precision medicine applications for specific ethnics. In order to quantify the HX1 misassembled genes and HX1-specific contigs, we performed RNA-seq and RNC-seq on hepatocellular carcinoma cell lines (MHCC97H, MHCCLM3 and MHCCLM6) which were derived from Chinese Han individuals. In which, RNC-seq datasets of MHCC97H and MHCCLM3 had been published. We found that a considerable fraction of HX1 misassembled genes was expressed in the Chinese Han samples. Furthermore, we found no HX1-specific contigs yielded more than 2.27 FPKM (minimun FPKM of 1 copy/cell transcript) in the Chinese Han sampels.

2019-06-01 | GSE121013 | GEO

PacBio RNAseq(IsoSeq) for 1000 Genome Trio Samples

Project description:PacBio RNAseq(IsoSeq) for 1000 Genome Trio Samples

| PRJEB13749 | ENA