Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

5'RACE E13.5 FH-Dicer

ABSTRACT: 5'RACE of E13.5 FH-Dicer

PROVIDER: PRJEB13567 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR1360124.fastq.gz	Fastqsanger.gz
	ERR1360125.fastq.gz	Fastqsanger.gz
	ERR1360126.fastq.gz	Fastqsanger.gz
	ERR1360127.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Expression in the dorsal telencephalon of E13.5 conditional Dicer KO mice

Project description:To study the effect of miRNA depletion in the embryonic forebrain, we isolated RNA from E13.5 dorsal telencephalon of mice homozygous for a floxed Dicer allele and hemizygous for the forebrain expressed Emx1Cre (Dicer KO mice). These samples were compared to littermates heterozygous for the floxed allele and hemizygous for Emx1Cre.

2012-08-30 | GSE37610 | GEO

Expression in the dorsal telencephalon of E13.5 conditional Dicer KO mice

2012-08-30 | E-GEOD-37610 | biostudies-arrayexpress

Mycoplasmoides pneumoniae FH strain:FH

Project description:Mycoplasmoides pneumoniae FH strain:FH Genome sequencing

| PRJNA182276 | ENA

Mycoplasmoides pneumoniae FH strain:FH

Project description:Mycoplasma pneumoniae FH Genome Sequencing

| PRJNA73095 | ENA

Mycoplasmoides pneumoniae FH strain:FH

Project description:Mycoplasma pneumoniae FH Genome sequencing

| PRJNA46155 | ENA

Mycoplasmoides pneumoniae FH strain:FH

Project description:Mycoplasma pneumoniae FH genome sequencing project

| PRJNA49525 | ENA

Genome-wide expression profile in FH-deficient (UOK262) vs FH-competent (UOK262pFH) human cells derived from metastatsis to the mediastinum of a HLRCC patient

Project description:Comparison of the transcriptome of human kideny cancer cells either wild-type for FH or FH-deficient. The UOK262 cells were isolated from mediastinum metastasis of a HLRCC patient (Yang et al. Cancer Genetics and Cytogenetics, Volume 196, Issue 1, 1 January 2010, Pages 45–55). FH function was restored in the UOK262 by re-expressing the FH transcript from an exogenous plasmid.

2016-09-22 | GSE77538 | GEO

The effect of FH mutations on fibroid expression profile, normal myometrium vs. FH-mutant fibroids.

Project description:A series of gene expression measurements of uterine fibroids with mutated fumarate hydratase (FH) gene and normal myometrium. Keywords: other

2005-12-20 | GSE2724 | GEO

HIRA loss transforms FH deficient cells [ChIP-Seq]

Project description:Fumarate Hydratase (FH) is a mitochondrial enzyme that catalyses the reversible hydration of fumarate to malate in the TCA cycle. Germline mutations of FH lead to HLRCC, a cancer syndrome characterised by a highly aggressive form of renal cancer(1). Although HLRCC tumours metastasise rapidly, FH-deficient mice develop premalignant cysts in the kidneys, rather than carcinomas(2). How Fh1-deficient cells overcome these tumour suppressive events during transformation is unknown. Here, we perform a genome-wide CRISPR/Cas9 screen to identify genes that, when ablated, enhance the proliferation of Fh1-deficient cells. We found that the depletion of the HIRA enhances proliferation and invasion of Fh1-deficient cells in vitro and in vivo. Mechanistically, Hira loss enables the activation of MYC and its target genes, increasing nucleotide metabolism specifically in Fh1-deficient cells, independent of its histone chaperone activity. These results are instrumental for understanding mechanisms of tumorigenesis in HLRCC and the development of targeted treatments for patients.

2022-10-29 | GSE203056 | GEO

Genome-wide expression profile in FH-deficient vs FH-competent cells

Project description:Genome-wide expression profile in FH-deficient vs FH-competent cells

| PRJNA310748 | ENA