Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Gardnerella vaginalis DSM 4944

PROVIDER: PRJEB16365 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	GCA_900105405.1_sequence_report.txt	Txt

Items per page:

1 - 1 of 1

Similar Datasets

Gardnerella vaginalis strain:dsm 4944

Project description:Gardnerella vaginalis DSM 4944 genome sequencing

| PRJNA303713 | ENA

Gardnerella vaginalis cell surface shaving

Project description:Study of Gardnerella vaginalis cell surface proteome

2018-06-06 | PXD003192 | Pride

mouse gut metagenome

Project description:Gardnerella vaginalis infection

| PRJNA1006870 | ENA

Gardnerella vaginalis

Project description:Gardnerella vaginalis overview

| PRJNA37367 | ENA

Gardnerella vaginalis activates host responses necessary for Escherichia coli recurrent UTI from bladder reservoirs

Project description:Recurrent urinary tract infections (rUTI) are a costly clinical problem affecting millions of women worldwide each year. The majority of rUTI cases are caused by uropathogenic Escherichia coli (UPEC). Data from humans and mouse models indicate that some instances of rUTI are caused by UPEC emerging from latent reservoirs in the bladder. Some studies have reported that women with vaginal dysbiosis, typically characterized by high levels of Gardnerella vaginalis and other anaerobes, are at increased risk of UTI. Multiple studies have detected G. vaginalis in urine collected by transurethral catheterization (to limit vaginal contamination), suggesting that some women experience routine urinary tract exposures. We recently reported that inoculation of G. vaginalis into the bladder triggers rUTI from UPEC bladder reservoirs in a mouse model. Here we performed whole bladder RNAseq to identify host pathways involved in G. vaginalis-induced rUTI. We identified multiple host pathways differentially expressed following G. vaginalis exposure. At the gene and transcript level, we identified upregulation of the orphan nuclear receptor Nur77 (aka Nr4a1) and Nur77-regulated genes. Pilot data from Nur77 knockout mice suggests that Nur77 is necessary for G. vaganalis exposure to trigger rUTI.

2021-11-01 | GSE186800 | GEO

Project description:Taxonomy of Gardnerella vaginalis

| PRJNA474758 | ENA

Gardnerella vaginalis 6420B

Project description:Gardnerella vaginalis 6420B genome sequencing

| PRJNA42441 | ENA

Gardnerella pickettii 00703Bmash

Project description:Gardnerella vaginalis 00703Bmash genome sequencing

| PRJNA42449 | ENA

Gardnerella vaginalis 41V

Project description:Gardnerella vaginalis 41V genome sequencing

| PRJNA53893 | ENA