Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Comparative study of Clostridium difficile

ABSTRACT: Comparative study of Clostridium difficile

PROVIDER: PRJEB1728 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR266111.fastq.gz	Fastqsanger.gz
	ERR266112.fastq.gz	Fastqsanger.gz
	ERR266113.fastq.gz	Fastqsanger.gz
	ERR266114.fastq.gz	Fastqsanger.gz
	ERR266115.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 9

Similar Datasets

Comparative study of Clostridium difficile - B1

Project description:Comparative study of Clostridium difficile - B1

| PRJEB1769 | ENA

Comparative study of Clostridium difficile - A-027

Project description:Comparative study of Clostridium difficile.

| PRJEB1768 | ENA

Comparative study of Clostridium difficile - Tra5/5

Project description:Comparative study of Clostridium difficile - Tra5/5

| PRJEB1770 | ENA

Comparative genomic hybridization of Clostridium difficile strains to identify markers of different ribotypes

Project description:Clostridium difficile (C. difficile) strains belonging to PCR ribotype 027, PFGE type NAP1, REA type B1 and toxinotype III, termed NAP1/027, have been implicated in the increased frequency of outbreaks of Clostridium difficile-associated diarrhoea (CDAD) in North America and Europe. The NAP1/027 strains appears to be more virulent with an increased mortality and frequency of relapse. Current European C. difficile microarrays are designed to the first sequenced and annotated C. difficile complete genome - strain 630 (ribotype 12). A high density oligonucleotide microarray was designed to C. difficile 630 (CD630) sequence and extra probes corresponding to two PCR ribotypes O27 strains C. difficile R20291 and QCD-32g58 were also included. Comparative genomic hybridisation was used to identify markers of ribotype 027 strains and markers to identify CD630. Strains hybridised to the array included the most prevalent ribotypes found in the UK and Europe (106 and 001) as well as the emerging hypervirulent ribotype 078.

2010-07-01 | E-MTAB-162 | biostudies-arrayexpress

Clostridium difficile strain 630 against various strains from different hosts

Project description:Clostridium difficile is a gram-positive, spore-forming enteric anaerobe which can infect humans and a wide variety of animal species. Recently, the incidence and severity of human C. difficile infection has markedly increased. In this study, we evaluated the genomic content of 73 C. difficile strains isolated from humans, horses, cattle, and pigs by comparative genomic hybridization with microarrays containing coding sequences from C. difficile strains 630 and QCD-32g58. The sequenced genome of C. difficile strain 630 was used as a reference to define a candidate core genome of C. difficile and to explore correlations between host origins and genetic diversity. Approximately 16% of the genes in strain 630 were highly conserved among all strains, representing the core complement of functional genes defining C. difficile. Absent or divergent genes in the tested strains were distributed across the entire C. difficile 630 genome and across all the predicted functional categories. Interestingly, certain genes were conserved among strains from a specific host species, but divergent in isolates with other host origins. This information provides insight into the genomic changes which might contribute to host adaptation. Due to a high degree of divergence among C. difficile strains, a core gene list from this study offers the first step toward the construction of diagnostic arrays for C. difficile.

2008-02-01 | GSE9693 | GEO

Clostridium difficile strain 630 against various strains from different hosts

2010-12-01 | GSE19343 | GEO

Human colon epithelial cells treated with Clostridium difficile Toxins A and B

Project description:Toxin A and B from Clostridium difficile are the primary virulence factors in Clostridium difficile disease. The changes in gene transcription of human colon epithelial cells were investigated in vitro in order to better understand the many effects of both toxins.

2012-01-06 | GSE29008 | GEO

Type IV pili promote early biofilm formation by Clostridium difficile

Project description:Transcriptional analysis of Clostridium difficile R20291 in biofilm formation, planktonic state and grown on blood agar RNA sequencing was performed on Clostridium difficile R20291 in three different conditions: Biofilm formation, plantonic state and grown on blood agar plates. Each condtion has 3 replicates.

2016-05-18 | E-GEOD-69001 | biostudies-arrayexpress

Global transcriptional control by the transcriptional regulator SinR in Clostridium difficile

Project description:Global transcriptional control by the transcriptional regulator SinR in Clostridium difficile

2018-12-25 | GSE100946 | GEO

Type IV pili promote early biofilm formation by Clostridium difficile

Project description:Transcriptional analysis of Clostridium difficile R20291 in biofilm formation, planktonic state and grown on blood agar

2016-05-18 | GSE69001 | GEO