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Nutritional programming of lifespan: Excessive sugar consumption in early adulthood curtails Drosophila survival by inhibiting dFOXO

ABSTRACT: Nutritional programming of lifespan: Excessive sugar consumption in early adulthood curtails Drosophila survival by inhibiting dFOXO

PROVIDER: PRJEB17620 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR1717100_1.fastq.gz	Fastqsanger.gz
	ERR1717100_2.fastq.gz	Fastqsanger.gz
	ERR1717110_1.fastq.gz	Fastqsanger.gz
	ERR1717110_2.fastq.gz	Fastqsanger.gz
	ERR1717101_1.fastq.gz	Fastqsanger.gz

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Nutritional programming of lifespan: Excessive sugar consumption in early adulthood curtails Drosophila survival by inhibiting dFOXO

Project description:Fruit flies were maintained either 40% sugar or 5% sugar diets for one week, then on 5% sugar for one further week. Whole flies were sampled at the end of weeks 1 and week 2. Persistent effects of past high sugar diets are identified.

2017-01-11 | E-MTAB-4766 | biostudies-arrayexpress

Transcriptional memory of dFOXO activation in youth curtails later-life mortality

Project description:Identifying processes occurring in early life affect subsequent life and health span is an urgent aim to improve human health. In this study, we identified a novel mechanism of dFOXO in longevity determination in Drosophila. We found that early adulthood induction of dFOXO is sufficient to reduce mortality in old age through different pathways than chronic dFOXO. We showed that dFOXO requires specific ATP-dependent chromatin modifiers to extend lifespan, and we could mimic this lifespan extension by modulating dFOXO’s targets in later life. Furthermore, dFOXO in early life induces a specific transcriptional programme that counteracts the natural transcriptomic changes occurring with age. Our findings provide a better understanding of transcriptional mechanisms related to longevity and opens new avenues for possible time-restricted interventions to improve human health in the future.

2022-09-28 | MTBLS3251 | MetaboLights

Transcriptional memory of dFOXO activity in early adulthood delays late life mortality.

Project description:Transcriptional memory of dFOXO activity in early adulthood delays late life mortality.

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Transcriptional memory of dFOXO activity in early adulthood delays late life mortality [RNA-seq]

Project description:The study examined transcriptional memory after dFOXO induction in fat body and gut of young adult female fruit flies.

2022-10-06 | GSE183541 | GEO

Transcriptional memory of dFOXO activity in early adulthood delays late life mortality [ATAC-seq]

Project description:The study examined transcriptional memory after dFOXO induction in fat body and gut of young adult female fruit flies.

2022-10-06 | GSE183540 | GEO

Transcriptional memory of dFOXO activity in early adulthood delays late life mortality [ATAC-seq]

Project description:Transcriptional memory of dFOXO activity in early adulthood delays late life mortality [ATAC-seq]

| PRJNA761204 | ENA

Transcriptional memory of dFOXO activity in early adulthood delays late life mortality [RNA-seq]

Project description:Transcriptional memory of dFOXO activity in early adulthood delays late life mortality [RNA-seq]

| PRJNA761205 | ENA

Genome-wide analysis of dFOXO binding sites in Drosophila

Project description:To understand how reduced insulin/IGF-1 signaling extends Drosophila lifespan through its downstream transcription factor dFOXO. We conducted ChIP analysis with a dFOXO antibody followed by Illumina high-throughput sequencing from chico heterozygous mutants, which are long-lived and normal sized, and from adult flies with ablated insulin producing cells (IPCs), which are also long-lived. dFOXO bound at promoters of 273 genes common among these genotypes, thus potentially enriching for shared factors in control of aging.

2013-09-20 | GSE44686 | GEO

Effect of aging and dFOXO knockout on small RNAs

Project description:To examine the effect of loss of dFOXO on the small RNA landscape of aging animals, we sequenced total small RNA collected from whole wildtype (wDah) and dFOXO-null (dfoxoΔ94) flies at young (5-6 days) and old (31 days) age.

2022-09-04 | GSE212493 | GEO

Effect of aging and dFOXO knockout on small RNA in Ago1 and Ago2 RNA-induced silencing complexes

Project description:To examine the effect of loss of dFOXO on Ago1 and Ago2 RISC loading in aging animals, we sequenced RNA immunoprecipitated from Ago1 and Ago2 RISC collected from whole wildtype (wDah) and dFOXO-null (dfoxoΔ94) flies at young (5 days) and old (35 days) age. dFOXO is a transcription factor that regulates Ago1 and Ago2 as well as lifespan.

2022-09-04 | GSE212492 | GEO

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