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ABSTRACT: Nitrosovibrio sp. Nv17

PROVIDER: PRJEB17764 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	FPIQ01.dat.gz	Other
	FPIQ01.fasta.gz	Fasta.gz
	FPIQ01.master.dat	Other
	FPIQ01.dat.gz	Other

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Nitrosovibrio

Project description:Nitrosovibrio sp. overview

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Nitrosovibrio sp. Nv17

Project description:Nitrosovibrio sp. Nv17 Genome sequencing

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Nitrosovibrio sp. Nv12

Project description:Nitrosovibrio sp. Nv12 Genome sequencing

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Nitrosovibrio sp. Nv4

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Nitrosovibrio sp. Nv6

Project description:Nitrosovibrio sp. 12 Nv6 genome sequencing

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Project description:Nitrosovibrio tenuis Nv1

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Nitrosovibrio tenuis strain:Nv1

Project description:Nitrosovibrio tenuis Nv1 genome sequencing

| PRJNA323348 | ENA

Differential sex-dependent regulation of the alveolar macrophage miRNome of SP-A2 and co-ex (SP-A1/SP-A2) and sex differences attenuation after 18h of ozone exposure

Project description:BACKGROUND: Human SP-A1 and SP-A2, encoded by SFTPA1 and SFTPA2 and their genetic variants differentially impact alveolar macrophage (AM) functions and regulation, including the miRNome. We investigated whether miRNome differences previously observed between AM from SP-A2 and SP-A1/SP-A2 mice are due to continued qualitative differences or a delayed response of mice carrying a single gene. METHODS: Human transgenic (hTG) mice, carrying SP-A2 or both SP-A genes and SP-A-KO mice were exposed to filtered air (FA) or O3. AM miRNA levels, target gene expression and pathways determined 18 h after O3 exposure. RESULTS: We found: (a) Differences in miRNome due to sex, SP-A genotype, and exposure; (b) miRNome of both sexes was largely downregulated by O3 ; co-ex had fewer changed (≥2X) miRNAs than either group. (c) the number and direction of expression of genes with significant changes in males and females in co-ex is almost the opposite of those in SP-A2; (iv) The same pathways were found in the studied groups; (e) O3 exposure attenuated sex differences; a higher number of genotype-dependent and genotype-independent miRNAs was common in both sexes after O3 exposure. CONCLUSION: Qualitative differences between SP-A2 and co-ex persist 18 h post-O3, and O3 attenuates sex differences.

2021-01-06 | GSE158401 | GEO

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