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Left ventricle transcriptomic analysis reveals the initial decline in V̇O2peak from its lifetime apex associates with connective tissue accumulation

ABSTRACT: Left ventricle transcriptomic analysis reveals the initial decline in V̇O2peak from its lifetime apex associates with connective tissue accumulation

PROVIDER: PRJEB17927 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR1731840.fastq.gz	Fastqsanger.gz
	ERR1731850.fastq.gz	Fastqsanger.gz
	ERR1731860.fastq.gz	Fastqsanger.gz
	ERR1731870.fastq.gz	Fastqsanger.gz
	ERR1731841.fastq.gz	Fastqsanger.gz

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Left ventricle transcriptomic analysis reveals the initial decline in VO2peak from its lifetime apex associates with connective tissue accumulation

Project description:Peak oxygen consumption (VO2peak) strongly predicts morbidity and mortality better than other established risk factors, yet all mechanisms associated with its age-related decline are unknown. Our lab has shown that VO2peak first begins to decrease at the same age of 19 weeks old in Wistar in both sedentary and wheel-running, female Wistar rats. Here, we employed RNA-sequencing to determine the extent to which transcriptomic alterations in the left ventricle associate with age-related decreases in VO2peak. Transcriptomic comparisons were made within both sedentary (SED) and wheel-running (RUN) rats between 19 and 27 wks (n= 5-8/group).

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