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Ageing liver RNAseq of C57BL/6 male mice in dietary restricted and an ad libitum diets

ABSTRACT: Ageing liver RNAseq of C57BL/6 male mice in dietary restricted and an ad libitum diets

PROVIDER: PRJEB20286 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR1912600_1.fastq.gz	Fastqsanger.gz
	ERR1912600_2.fastq.gz	Fastqsanger.gz
	ERR1912610_1.fastq.gz	Fastqsanger.gz
	ERR1912610_2.fastq.gz	Fastqsanger.gz
	ERR1912601_1.fastq.gz	Fastqsanger.gz

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Ageing liver RNAseq of C57BL/6 male mice in dietary restricted and an ad libitum diets

Project description:45 mice were fed constantly (Ad libitum; AL) while a second group of mice were fed 30% less from month 3 of age (Dietary restricted; DR). Tissues were collected from mice of all groups at 3 and 15 months of age. A group of mice from AL and DR at 12 months were moved to the opposite diet and sequenced at 15 months.

2017-05-04 | E-MTAB-5645 | biostudies-arrayexpress

Expression data from Paneth cells isolated from mice on calorie restricted or ad libitum diet

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Expression data from ad libitum or restricted fed 16-week old broiler breeder hens

Project description:Ovarian dysfunction is observed in broiler breeder hens fed ad libitum that is most apparent by a reduction in fertility success. Restricting caloric intake in these hens is currently the only effective treatment to improve reproductive efficiency. This analysis sought to determine the transcriptional changes in the ovarian cortex of prepubertal hens given full access to feed (FF) or were placed on a restricted feed (RF) diet. Microarrays were employed to detail the differences in global gene expression that underlie the ovarian dysfunction observed in ad libitum fed hens.

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Transcriptome analysis in calorie-restricted rats implicates epigenetic and post-translational mechanisms in neuroprotection and aging

Project description:Using RNA-seq, 39 cerebral cortex RNA samples were sequenced. The study design was as follows: Ad libitum fed rats at 6 months (n=3, 6 individuals pooled), 12 months (n=3, 6 individuals pooled) and 28 months (n=3, 6 individuals pooled). Calorie restricted rats at 6 months (n=3, 6 individuals pooled), 12 months (n=3, 6 individuals pooled) and 28 months (n=3, 6 individuals pooled). Rats fed alpha lipoic acid as a supplement to ad libitum at 12 months (n=3, 6 individuals pooled) and 28 months (n=3, 6 individuals pooled). Diet switching groups, where diet was changes at 12 months; 28 month ad libitum switched to calorie restriction (n=3, 6 individuals pooled), 28 month calorie restriction switched to ad libitum (n=3, 6 individuals pooled), 28 month ad libitum plus lipoic acid switched to calorie restriction (n=3, 6 individuals pooled), 28 month calorie restriction switched to ad libitum plus lipoic acid (n=3, 6 individuals pooled). Transcriptional profiling of the ageing cerebral cortex at 6, 12 and 28 months and the effect of diet on age and longevity, using carlorie restriction and alpha lipoic acid supplementation

2015-11-22 | E-GEOD-57110 | biostudies-arrayexpress

Age Map, Spinal Cord (B)

Project description:To assess the transcriptional changes in different brain regions and spinal cord associated with aging and either a caloric restricted (CR) or ad libitum (AL) diet. cDNA microarray and quantitative PCR analyses were used to examine the transcriptomes of various neuronal tissues in young, middle aged and old mice. Mice of both genders were examined as well as the effects of their placement on either caloric restricted (CR) or ad libitum (AL) diets. To assess the transcriptional changes in different brain regions and spinal cord associated with aging and either a caloric restricted (CR) or ad libitum (AL) diet. cDNA microarray and quantitative PCR analyses were used to examine the transcriptomes of various neuronal tissues in young, middle aged and old mice. Mice of both genders were examined as well as the effects of their placement on either caloric restricted (CR) or ad libitum (AL) diets. Keywords: age-, gender-, and diet- comparison

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Plane of nutrition prepartum and bovine hepatic gene expression profiles

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Two different 4-week energy-restricted diets.

Project description:The main aim of this experiment was to investigate gene expression on human adipose tissue after two different 4-week energy-restricted diets. Our questions consisted in understanding how gene expression was linked to clinical parameters of obese patients and whether the two diets were discriminated this data. The subjects were randomly allocated, in a cross-over design, to two periods of 4 weeks of an energy restricted isocaloric diet of 1200 kcal as either a conventional diet (LC-CONV) or a special energy restricted diet compensated by proteins (LC-P-LGI). The two nutritional periods were separated by a wash-out interval of 8 weeks. The samples who contain a K in their name correspond to the LC-P-LGI diet while those who contain a C correspond to LC-CONV diet.

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Comparing the effects of low protein, high carbohydrate diets and caloric restriction on brain aging in mice.

Project description:Calorie restriction (CR) increases lifespan and improves brain health in mice. Ad libitum low protein, high carbohydrate (LPHC) diets also extend lifespan, but it is not known whether they are beneficial for brain health. We compared hippocampus biology and memory in mice subjected to 20% CR or provided ad libitum access to one of three LPHC diets, or to a control diet. At age 15 months, patterns of RNA expression in the hippocampus were similar between CR and LPHC diets for genes associated with longevity, cytokines and dendrite morphogenesis. Nutrient sensing proteins including SIRT1, mTOR and PGC1α were also influenced by diet, however the effects varied by sex. CR and LPHC diets were associated with increased dendritic spines in dentate gyrus neurons. CR and LPHC diets led to modest improvements in the Barnes Maze and Novel Object Recognition. LPHC diets recapitulate some of the benefits of CR on brain aging.

2018-10-18 | GSE111778 | GEO

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