Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Pneumococcal in morbus diversity (QEH, Blantyre, Malawi)

ABSTRACT: Pneumococcal in morbus diversity (QEH, Blantyre, Malawi)

PROVIDER: PRJEB2110 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	ERR024491_1.fastq.gz	Fastqsanger.gz
	ERR024491_2.fastq.gz	Fastqsanger.gz
	ERR024492_1.fastq.gz	Fastqsanger.gz
	ERR024492_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 97

Similar Datasets

Malawi pneumococcal genomic snapshot

Project description:Malawi pneumococcal genomic snapshot

| PRJEB2131 | ENA

Project description:PCVPA Blantyre, Malawi pneumococcal carriage surveillance study

| PRJNA1011974 | ENA

Genome wide transcriptional profiling of HIV positive and negative children with active tuberculosis, latent TB infection and other diseases from South Africa and Malawi

Project description:The study aimed to define transcriptional signatures for detection of active TB (TB) compared to latent TB infection (LTBI) as well as to other diseases (OD) with similar clinical phenotypes in patients with and without HIV in two African paediatric populations. Transcriptional signatures were identified that distinguished active TB from LTBI, and active TB from other diseases. Children were recruited from Cape Town, South Africa (n=157) and Blantyre, Malawi (n=177) who were either HIV+ or HIV - with either active TB, LTBI or OD. Blood was collected into PAX gene tubes (PreAnalytiX). Total RNA integrity was assessed using an Agilent 2100 Bioanalyzer (Agilent, Palo Alto, CA). Labeled cRNA was hybridized to Illumina Human HT-12 Beadchips. Data were analysed in R.

2014-05-01 | E-GEOD-39940 | biostudies-arrayexpress

Homo sapiens strain:(MAB) malawian in Blantyre, Malawi

Project description:Exome sequencing of (MAB) malawian in Blantyre, Malawi HapMap population

| PRJNA59813 | ENA

Genetic diversity on Streptococcus pneumoniae in Malawi 2

Project description:Genetic diversity on Streptococcus pneumoniae in Malawi 2

| PRJEB2098 | ENA

Homo sapiens strain:(MAB) malawian in Blantyre, Malawi

Project description:Whole genome sequencing of (MAB) malawian in Blantyre, Malawi HapMap population

| PRJNA42577 | ENA

Streptococcus pneumoniae genetic diversity and invasive pneumococcal disease

Project description:Streptococcus pneumoniae genetic diversity and invasive pneumococcal disease

| PRJEB3259 | ENA

Genomic diversity of a pneumococcal clonal complex, 199

Project description:Comparative genomic hybridisation of Streptococcus pneumoniae isolates from a single clonal complex, in order to determine genomic diversity. Isolates were selected from a range of tissue types and serotypes in order to cover the full diversity of the clone, and also in order to try and identify tissue-specific genes

2010-09-07 | GSE23992 | GEO

Hepatitis C in Blantyre, Malawi

Project description:A clinical and molecular epidemiological survey of hepatitis C in Blantyre, Malawi suggests an historic mechanism of transmission

| PRJEB47689 | ENA

In vitro gene exoression comparison between the ST217 serotype 1 strain A42174 and the serotype 2 strain D39.

Project description:Streptococcus pneumoniae is a frequent coloniser of the human nasopharynx and a major cause of life-threating invasive infections such as pneumonia, meningitis and sepsis. Over 1 million people die every year due to invasive pneumococcal disease (IPD), mainly in developing countries. Serotype 1 is a common cause of IPD; however, unlike other serotypes, it is rarely found in the carrier state in the nasopharynx, which is often considered a prerequisite for disease. The aim of this study was to understand this dichotomy. We used murine models of carriage and IPD to characterise the pathogenesis of African serotype 1 (Sequence Type 217) pneumococcal strains obtained from the Queen Elizabeth Central Hospital in Blantyre, Malawi. We found that ST217 pneumococcal strains were highly virulent in a mouse model of invasive pneumonia, but in contrast to the generally accepted assumption, can also successfully establish nasopharyngeal carriage. Interestingly, we found that co-colonising serotypes may proliferate in the presence of serotype 1, suggesting that acquisition of serotype 1 carriage could increase the risk of developing IPD by other serotypes. RNAseq analysis confirmed that key virulence genes associated with inflammation and tissue invasiveness were upregulated in serotype 1. These data reveal important new insights into serotype 1 pathogenesis, with implications for carriage potential and risk of invasive disease through interactions with other co-colonising serotypes; an often overlooked factor in transmission and disease progression.

2020-11-12 | GSE159305 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data