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Effect of IMP2 overexpression in murine liver

ABSTRACT: Transgenic expression of the RNA binding protein IMP2 stabilizes miRNA targets in murine microsteatosis

PROVIDER: PRJEB21164 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	ERR2264300.fastq.gz	Fastqsanger.gz
	ERR2264310.fastq.gz	Fastqsanger.gz
	ERR2264790.fastq.gz	Fastqsanger.gz
	ERR2264301.fastq.gz	Fastqsanger.gz

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Next Generation Sequencing (NGS) analysis of mice pancreatic islets from control and IMP2 islet specific knockout (Rip2;IMP2).

Project description:The goal of this study is to understand how IMP2 contributes to T2D traits by regulating pancreatic beta cell growth and function. Islets from control and Rip2;IMP2 mice were generated by deep sequencing. In additon, we also perfomred IMP2 RIP-Seq to identify IMP2 targets.

2023-06-11 | GSE152424 | GEO

RNA expression profile of liver-specific IGF2BP2/IMP2/p62 transgenic mice compared to wild-type mice

Project description:Livers of p62/IMP2-2 transgenic mice with C57Bl6J/DBA2 background as described in Tybl et al., J Hepatol, 2011

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IMP2 axonal localization, RNA interactome, and function in development of axon trajectories

Project description:RNA-based regulatory mechanisms play important roles in the development and plasticity of neural circuits and neurologic disease. Developing axons provide a well suited model to study RNA-based regulation, and contain specific subsets of mRNAs that are locally translated and have roles in axon pathfinding. However, the RNA-binding proteins involved in axon pathfinding, and their corresponding mRNA targets, are still largely unknown. Here we find that the RNA-binding protein IMP2 (Igf2bp2) is strikingly enriched in developing axon tracts, including in spinal commissural axons. We used the HITS-CLIP approach to perform a genome-wide identification of RNAs that interact directly with IMP2 in the native context of developing brain. This IMP2 interactome was highly enriched for mRNA targets related to axon guidance. Accordingly, IMP2 knockdown in the developing spinal cord led to strong defects in commissural axon trajectories at the midline intermediate target. These results reveal a highly distinctive axonal enrichment of IMP2, show that it interacts with a network of axon guidance-related mRNAs, and reveal its requirement for normal axon pathfinding during vertebrate development. CLIP-seq

2016-08-02 | E-GEOD-83822 | biostudies-arrayexpress

IMP2 axonal localization, RNA interactome, and function in development of axon trajectories

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IMP2-TRIBE

Project description:Detection of IMP2 binding sites

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Quantitative proteomes of Imp2 KO mouse 2-cell-stage embryos

Project description:Data showing the late 2-cell-stage, control embryos (Imp2♀+/♂+) and Imp2-knockout embryos (Imp2♀−/♂+) for HPLC MS/MS analysis. 3 replicates were performed using 330 embryos per group.

2019-11-12 | PXD010397 | Pride

IMP2/IGF2BP2 HITS-CLIP from E13.5 mouse brain

Project description:HITS-CLIP is performed for the RNA-binding protein, IMP2/IGF2BP2, from E13.5 mouse brain.

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Functional characterization of RNA-binding protein IMP2 in primary Glioma cell lines [array]

Project description:Cancer stem cells (CSC) dictate tumor cell heterogeneity in diverse cancer types and arise, in part, from microRNA (miRNA)-dependent alteration of gene expression. The let-7 miRNA family induces differentiation by silencing genes that maintain stemness and is repressed by the RNA-binding proteins LIN28A/B, which preserve stemness in normal embryonic and malignant cells. Here, we observed that LIN28A/B is undetectable in glioma stem cells (GSC) whereas let-7 and, paradoxically, their target genes are highly expressed. Using photoactivatable-ribonucloside-enchanced crosslinking and immunoprecipitation (PAR-CLIP), we show that insulin-like growth factor-2 mRNA-binding protein 2 (IMP2) protects let-7 target genes from silencing and provides a mechanistically distinct alternative to LIN28A/B toward both GSC and neural stem cell specification. Our observations define the RNA-binding repertoire of IMP2 and identify a mechanism by which it supports GSC maintenance.

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Functional characterization of RNA-binding protein IMP2 in primary Glioma cell lines [HTS]

2016-05-12 | GSE73845 | GEO

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Project description:Imp2 -/- mice were subjected to a number of characterization assays, including RNA-Seq of various tissues, Characterization of IMP2 -/- mice including various metabolic measurements.

2015-03-03 | E-GEOD-66440 | biostudies-arrayexpress

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