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TIM2_iron_study metagenomic assembly

ABSTRACT: EMG produced TPA metagenomics assembly of the Gut microbial metabolism shifts towards a more toxic profile with supplementary iron in a kinetic model of the human large intestine (TIM2_iron_study) data set

PROVIDER: PRJEB22501 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR537009.fasta.gz	Fasta.gz
	ERR537010.fasta.gz	Fasta.gz
	ERR537006.fasta.gz	Fasta.gz

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TIM2_iron_study

Project description:Gut microbial metabolism shifts towards a more toxic profile with supplementary iron in a kinetic model of the human large intestine

| PRJEB6542 | ENA

The response of intestinal microbiota and immunity to increasing dietary iron in piglets

Project description:Iron is an essential metal for both animals and microbiota, and neonates and infants of humans and animals, in general, are at the risk of iron insufficient. However, excess dietary iron usually causes negative impacts on the host and microbiota. This study aimed to investigate over-loaded dietary iron supplementation on growth performance, the distribution pattern of iron in the gut lumen and the host, intestinal microbiota, and intestine gene expression profile of piglets. Sixty healthy weaning piglets were randomly assigned to six groups: fed with diets supplemented with ferrous sulfate monohydrate at the dose of 50ppm (Fe50 group), 100ppm (Fe100 group), 200ppm (Fe200 group), 500ppm (Fe500 group), and 800ppm (Fe800) for three weeks. The results indicated that increasing iron had no effects on growth performance but increased diarrheal risk and iron deposition in intestinal digesta, tissues of intestine and liver, and serum. High iron also reduced serum iron-binding capacity, apolipoprotein, and immunoglobin A. The RNA-sequencing analysis revealed that iron changed colonic gene expression profile, such as interferon gamma-signal transducer and activator of transcription 2 based anti-virus and bacteria gene network. Increasing iron also shifted cecal and colonic microbiota, such as reducing alpha diversity, Clostridiales and Lactobacillus reuteri, and increasing Lactobacillus and Lactobacillus amylovorus. Collectively, this study demonstrated that high dietary iron increased diarrheal incidence, changed intestinal immune response-associated gene expression, and shifts gut microbiota. The results would enhance our knowledge of iron effects on the gut and microbiome in piglets, and further contribute to understanding these aspects in humans.

2020-09-20 | GSE158245 | GEO

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Project description:EMG produced TPA metagenomics assembly of the stool samples Raw sequence reads (stool) data set

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Project description:EMG produced TPA metagenomics assembly of the Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life (InfantGut) data set

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