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Effect of infection and treatment of Teladorsagia circumcincta on Ovine intestinal microbiota.

ABSTRACT: Effect of infection with and treatment of sensitive and resistant strains of Teladorsagia circumcincta on the ovine intestinal microbiota

PROVIDER: PRJEB24185 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR2233530_1.fastq.gz	Fastqsanger.gz
	ERR2233530_2.fastq.gz	Fastqsanger.gz
	ERR2233540_1.fastq.gz	Fastqsanger.gz
	ERR2233540_2.fastq.gz	Fastqsanger.gz
	ERR2233550_1.fastq.gz	Fastqsanger.gz

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Teladorsagia circumcincta

Project description:Teladorsagia circumcincta overview

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Teladorsagia circumcincta transcriptomics

Project description:This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/ Teladorsagia circumcincta, the brown stomach worm, is the most important gastro-intestinal parasite of sheep in temperate regions and is present on 100% of sheep farms in the UK. Infection with T. circumcincta causes a spectrum of disease in the host, ranging from weight loss to death, and results in significant production losses. Parasitic disease is currently controlled by treatment with anthelmintics but resistance to these drugs is widespread and threatens the viability of the livestock industry. There are now well-documented cases of UK farms harbouring triple-resistant T. circumcincta, which can no longer be controlled by any of the three major anthelmintic classes, forcing farmers to abandon sheep rearing. High-throughput sequencing of life stages of T. circumcincta will be used for gene finding and transcriptome analysis.

2015-06-30 | E-ERAD-342 | biostudies-arrayexpress

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Project description:Genome sequencing of the drug resistant nematode Teladorsagia circumcincta.

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Project description:Teladorsagia circumcincta niche specific expression

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Teladorsagia circumcincta strain:field strain | isolate:NZ_Teci_NP

Project description:Teladorsagia circumcincta strain:field strain | isolate:NZ_Teci_NP Genome sequencing

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pamknight ovine abomasum1

Project description:To address the protective mechanisms generated in animals on previous exposure to this parasite, using samples of abomasal mucosa collected pre- and post- challenge from animals of differing immune status in an experimental model of Teladorsagia circumcincta infection.

2011-05-20 | E-TABM-1149 | biostudies-arrayexpress

A differential polarization of Th1, Th2 and Treg immune response determines resistance and susceptibility of sheep breeds to Teladorsagia circumcincta infection

Project description:Gastrointestinal nematode (GIN) is a major economic and health concern is sheep farming. Sheep breeds such as Texel are relatively resistant to GIN than the Suffolk. With the objective to understand the underlying genetic mechanism of resistance and susceptibility at the transcriptomic level, two groups of animal from both the breed were artificially (orally) infected with 30,000 L3 larvae of prominent GIN Teladorsagia circumcincta. Subgroups of animals from each breed were slaughtered on day 0, 3, 7, 14 and 21 of post infection (p.i.). Transcriptomic profiling of abomasal lymph node was performed using RNA-seq. The perturbations in gene expression profiles in both the breeds were evident and Texel showed a more tightly regulated immune response than the Suffolk. The number of differentially expressed (DE) genes between the breeds was highest (437) on un-infected control (day 0) and lowest (173) on day 7 p.i.. Pathway analysis of DE genes identified 3 significant pathways, which involved only more highly expressed genes of Suffolk breed on day 0 and only more highly expressed genes of Texel (with one exception) on day 7 p.i.. The Th1, Th2 and Treg response was evident in response to GIN in Texel and was synchronized, while in Suffolk Th1 response was reduced after infection and pronounced Th2 and Treg was not evident. The study suggests maximum level of transcriptional activity in both breeds on day 7 p.i. and there was a shift of transcriptional activity from Suffolk on day 0 to Texel on day 7 p.i.. Suffolk had a reduced Th1 response with less pronounced Th2 and Treg immune response, while Texel had an active and synchronized Th1/Th2/Treg immune response in response to GIN infection. Abomasal lymph node tissue was taken from control (n=10) and experimentally infected (with T. circumcincta) lambs (n=36) from Texel and Suffolk breed on day 0, 3, 7, 14 and 21 post infection.

2014-01-01 | E-GEOD-43241 | biostudies-arrayexpress

A differential polarization of Th1, Th2 and Treg immune response determines resistance and susceptibility of sheep breeds to Teladorsagia circumcincta infection

2014-01-01 | GSE43241 | GEO