Project description:The aim of this study was to investigate the response of human brain endothelial cells to bacterial (group B streptococcus, GBS) infection. Results: GBS WT strain infection results in a specific gene induction pattern that is different from the pilA mutant, but not other mutants such as pilB and srr-1. Conclusion: These findings suggest that the GBS PilA protein contributes to gene induction in brain endothelium.

2011-09-06 | E-MTAB-765 | biostudies-arrayexpress

Gene expression-based global role of CovR in GBS A909

Project description:Global regulatory roles of the TCS response regulator CovR in GBS serotype 1a A909 Keywords: Strain comparison; global regulation

2007-10-18 | GSE9370 | GEO

ChIP-seq of the response regulator CovR in Group B Streptococcus (GBS)

Project description:We report the characterization of the major regulator of virulence gene expression (CovR) in Group B Streptococcus. The ChIP-seq experiments define the binding of CovR on the chromosome of the BM110 strain, a representative of the hypervirulent GBS lineage responsible of neonatal meningitis. Regulatory evolution of CovR signaling was investigated by comparing ChIP-seq done in parallel in a second GBS clinical isolate (NEM316) not belonging to the hypervirulent lineage.

2021-08-23 | GSE158046 | GEO

Armatimonadetes bacterium GBS isolate:GBS

Project description:Armatimonadetes bacterium GBS isolate:GBS Genome sequencing and assembly

| PRJNA285317 | ENA

A vaginal tract signal detected by the GBS SaeRS system elicits transcriptomic changes and enhances murine colonization.

Project description:Streptococcus agalactiae (Group B Streptococcus, GBS) can colonize the human vaginal tract leading to both superficial and serious infections in adults and neonates. To study bacterial colonization of the reproductive tract in a mammalian system, we employed a murine vaginal carriage model. Using RNASeq, the transcriptome of GBS growing in vivo during vaginal carriage was determined. Over one-quarter of the genes in GBS were found to be differentially regulated during in vivo colonization as compared to laboratory cultures. A two-component system (TCS) homologous to the staphylococcal virulence regulator SaeRS was identified as being up-regulated in vivo. One of the SaeRS targets, pbsP, a proposed GBS vaccine candidate, was shown to be important for colonization of the vaginal tract. A component of vaginal lavage fluid acted as a signal to turn on pbsP expression via SaeRS. These data demonstrate the ability to quantify RNA expression directly from the murine vaginal tract and identify novel genes involved in vaginal colonization by GBS. They also provide more information about the regulation of an important virulence and colonization factor of GBS, pbsP, by the TCS SaeRS.

2018-02-06 | GSE109680 | GEO

GBS-Dioscorea

Project description:GBS Dioscorea dumetorum

| PRJEB27526 | ENA

Gene expression-based global role of CovR in GBS A909 using stk1 deletion mutant

Project description:Global regulatory roles of the TCS response regulator CovR in GBS serotype 1a A909 Keywords: Strain comparison; global regulation

2010-08-14 | GSE12463 | GEO

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