Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mtbc in Kinshasa

ABSTRACT: Mycobacterium tuberculosis isolates from Kinshasa,DRC

PROVIDER: PRJEB27847 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR2706910_1.fastq.gz	Fastqsanger.gz
	ERR2706910_2.fastq.gz	Fastqsanger.gz
	ERR2706920_1.fastq.gz	Fastqsanger.gz
	ERR2706920_2.fastq.gz	Fastqsanger.gz
	ERR2706930_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 648

Similar Datasets

Mycobacterium tuberculosis Complex Clinical Isolates exhibit unique gene expression profiles in vitro and inside macrophages

Project description:This SuperSeries is composed of the following subset Series: GSE21111: Basal in vitro transcriptomes of Mycobacterium tuberculosis complex (MTC) clinical isolates GSE21112: Intracellular transcriptional adaptation of Mycobacterium tuberculosis complex (MTC) clinical isolates inside resting murine macrophages GSE21113: Intracellular transcriptional adaptation of Mycobacterium tuberculosis complex (MTC) clinical isolates inside activated murine macrophages Refer to individual Series

2010-07-09 | E-GEOD-21114 | biostudies-arrayexpress

Mycobacterium tuberculosis clinical isolates in China: extensively drug-resistant tuberculosis vs drug sensitive one

Project description:Transcriptional profiling of mycobacterium tuberculosis clinical isolates in China comparing extensively drug-resistant tuberculosis with drug sensitive one.

2009-04-04 | GSE15540 | GEO

MTBC Lineages

Project description:Genomic evidence for lineage-specific adaptation in Mycobacterium tuberculosis

| PRJEB9003 | ENA

Functional genotyping of MTBC

Project description:Functional genotyping of Mycobacterium tuberculosis complex

| PRJEB5700 | ENA

Mapping of genotype-phenotype diversity amongst clinical isolates of Mycobacterium tuberculosis by RNA-seq

Project description:Mapping of genotype-phenotype diversity amongst clinical isolates of Mycobacterium tuberculosis by RNA-seq

2013-09-19 | E-MTAB-1446 | biostudies-arrayexpress

Mycobacterium tuberculosis clinical isolates in China: extensively drug-resistant tuberculosis vs drug sensitive one

Project description:Transcriptional profiling of mycobacterium tuberculosis clinical isolates in China comparing extensively drug-resistant tuberculosis with drug sensitive one. The same condition experiment. The samples were from the different drug-resistant strains. Only one replicate.

2009-04-04 | E-GEOD-15540 | biostudies-arrayexpress

Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli

Project description:In Mycobacterium tuberculosis, the PhoPR two-component regulatory system controls production and secretion of proteins and lipid virulence effectors. Several mutations, present in phoR of Mycobacterium canettii relative to M. tuberculosis, impact the expression of the PhoP regulon and the pathogenicity of the strains. Here, we analyse by RNA-seq the expression profile of PhoP-regulated genes between the two M. tuberculosis strains H37Rv and HN878 and the two M. canettii isolates STB-Ks and STB-Kr.

2023-05-24 | GSE229680 | GEO

Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production

Project description:Tuberculosis (TB) remains a deadly disease. The genetic diversity of Mycobacterium tuberculosis was neglected in the past, but is increasingly recognized as a determinant of immune responses and clinical outcomes of TB. However, how this bacterial diversity orchestrates immune responses to direct differences in TB severity remains unknown. We studied 681 patients with pulmonary TB and found that phylogenetically related M. tuberculosis isolates from cases with mild disease induced robust cytokine responses in macrophages. In contrast, isolates associated with severe TB cases failed to do so. Using representative isolates, we show that M. tuberculosis inducing a low cytokine response in macrophages also diminished activation of cytosolic surveillance systems, including cGAS and the inflammasome, suggesting a novel mechanism of immune escape. Isolates exhibiting this evasion strategy carried mutations in various components of the ESX-I secretion system. We conclude that host interactions with different M. tuberculosis strains results in variable TB severity.

2020-02-26 | GSE138580 | GEO

MTBC L3 population structure

Project description:Whole genome sequencing analysis of Mycobacterium tuberculosis lineage 3 strains

| PRJEB42771 | ENA

Project description:Mycobacterium tuberculosis isolates

| PRJNA1028254 | ENA